Rat CD192/CCR2 Recombinant Protein (N-GST & C-His)
- Catalog number: PR10033
- Availability: In Stock
$211.00
- Ex Tax: $211.00
- Description: Recombinant Rat CD192/CCR2 Protein, N-GST & C-His (PR10033) expressed in E. coli. Purity: >90% by SDS-PAGE.
Highlights:
• His-Tagged — N-terminal 6×His tag for IMAC purification.
• E. coli Expression — High-yield, cost-effective production.
• High Purity — >90% purity verified by SDS-PAGE. - Form: Lyophilized
- Storage buffer: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
- Purity: >90% as determined by SDS-PAGE.
- Applications: ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
- Endotoxin level: Please contact with the lab for this information.
- Expression system: E. coli
- Protein length: [Met1-Pro60] & [Glu323-Leu373]
- Predicted molecular weight: 40.99 kDa
- Stability and Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
- Reconstitution: Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
- Alternative Names: C-C chemokine receptor type 2; C-C CKR-2; CC-CKR-2; CCR-2; CCR2; CD192; Ccr2; Cmkbr2
- Species: Rattus norvegicus (Rat)
- Shipping: In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
- Background: C-C chemokine receptor type 2 (CD192/CCR2) is a ~42 kDa protein. Key functional receptor for CCL2 but can also bind CCL7 and CCL12. Its binding with CCL2 on monocytes and macrophages mediates chemotaxis and migration induction through the activation of the PI3K cascade, the small G protein Rac and lamellipodium protrusion. Also acts as a receptor for the beta-defensin DEFB106A/DEFB106B. Regulates the expression of T-cell inflammatory cytokines and T-cell differentiation, promoting the differentiation of T-cells into T-helper 17 cells (Th17) during inflammation. Facilitates the export of mature thymocytes by enhancing directional movement of thymocytes to sphingosine-1-phosphate stimulation and up-regulation of S1P1R expression; signals through the JAK-STAT pathway to regulate FOXO1 activity leading to an increased expression of S1P1R.
- Note: For research use only.
Images
-
SDS-PAGESDS-PAGE for Recombinant Rat CD192/CCR2 Protein, N-GST & C-His
