Anti-Human ANGPT2 Reference Antibody (AT006)
- Catalog number: BS10962
- Availability: In Stock
$370.00
- Ex Tax: $370.00
Description: Anti-Human ANGPT2 (AT006) (BS10962) is a research-grade recombinant antibody targeting ANG-2. Produced in mammalian cells with native-like glycosylation.
Highlights:
• Research Grade — For PK/PD studies, assay development, and ADA research.
• Native Glycosylation — Mammalian expression ensures native-like patterns.
Host species: Human
Isotype: IgG
Species reactivity: Human
Immunogen:
Form: Liquid
Storage instructions:
Storage buffer: 0.01M PBS, pH7.4.
Concentration: 1mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: Research Grade Biosimilar
Target: ANG-2,ANGPT2,Angiopoietin-2
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: <1EU/mg, determined by LAL gel clotting assay
Expression system: Mammalian Cells
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names: AT006
Background: Angiopoietin-2 (ANGPT2/ANG-2) is a ~56 kDa protein. Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal. Involved in the regulation of lymphangiogenesis.
References:
1. Lee, HJ. et al. (2004) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 18, 1200-8. PMID: 1528422
2. Yacyshyn, OK. et al. (2009) Angiogenesis 12, 25-33. PMID: 19116766
3. Yuan, HT. et al. (2009) Molecular and cellular biology 29, 2011-22. PMID: 19223473
4. Maisonpierre, PC. et al. (1997) Science (New York, N.Y.) 277, 55-60. PMID: 9204896
5. Leppänen, VM. et al. (2020) Science translational medicine 12. PMID: 32908006
Note: For research use only. Not suitable for clinical or therapeutic use.
Highlights:
• Research Grade — For PK/PD studies, assay development, and ADA research.
• Native Glycosylation — Mammalian expression ensures native-like patterns.
Host species: Human
Isotype: IgG
Species reactivity: Human
Immunogen:
Form: Liquid
Storage instructions:
Storage buffer: 0.01M PBS, pH7.4.
Concentration: 1mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: Research Grade Biosimilar
Target: ANG-2,ANGPT2,Angiopoietin-2
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: <1EU/mg, determined by LAL gel clotting assay
Expression system: Mammalian Cells
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names: AT006
Background: Angiopoietin-2 (ANGPT2/ANG-2) is a ~56 kDa protein. Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal. Involved in the regulation of lymphangiogenesis.
References:
1. Lee, HJ. et al. (2004) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 18, 1200-8. PMID: 1528422
2. Yacyshyn, OK. et al. (2009) Angiogenesis 12, 25-33. PMID: 19116766
3. Yuan, HT. et al. (2009) Molecular and cellular biology 29, 2011-22. PMID: 19223473
4. Maisonpierre, PC. et al. (1997) Science (New York, N.Y.) 277, 55-60. PMID: 9204896
5. Leppänen, VM. et al. (2020) Science translational medicine 12. PMID: 32908006
Note: For research use only. Not suitable for clinical or therapeutic use.
Images
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SDS-PAGESDS-PAGE for Research Grade Anti-Human ANGPT2 (AT006)
