Anti-Human CD317/BST2 Reference Antibody (XmAb 5592)
- Catalog number: BS10985
- Availability: In Stock
$370.00
- Ex Tax: $370.00
Description: Anti-Human CD317/BST2 (XmAb 5592) (BS10985) is a research-grade recombinant antibody targeting CD317. Produced in mammalian cells with native-like glycosylation.
Highlights:
• Research Grade — For PK/PD studies, assay development, and ADA research.
• Native Glycosylation — Mammalian expression ensures native-like patterns.
Host species: Human
Isotype: IgG
Species reactivity: Human
Immunogen:
Form: Liquid
Storage instructions:
Storage buffer: 0.01M PBS, pH7.4.
Concentration: 1mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: Research Grade Biosimilar
Target: Tetherin,Bonemarrowstromalantigen2,BST2,BST-2,CD317,HM1.24antigen
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: <1EU/mg, determined by LAL gel clotting assay
Expression system: Mammalian Cells
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names: XmAb-5592,XmAb5592,XmAb5592
Background: Bone marrow stromal antigen 2 (CD317/BST2) is a ~19 kDa protein. IFN-induced antiviral host restriction factor which efficiently blocks the release of diverse mammalian enveloped viruses by directly tethering nascent virions to the membranes of infected cells. Acts as a direct physical tether, holding virions to the cell membrane and linking virions to each other. The tethered virions can be internalized by endocytosis and subsequently degraded or they can remain on the cell surface. In either case, their spread as cell-free virions is restricted. Its target viruses belong to diverse families, including retroviridae: human immunodeficiency virus type 1 (HIV-1), human immunodeficiency virus type 2 (HIV-2), simian immunodeficiency viruses (SIVs), equine infectious anemia virus (EIAV), feline immunodeficiency virus (FIV), prototype foamy virus (PFV), Mason-Pfizer monkey virus (MPMV), human T-cell leukemia virus type 1 (HTLV-1), Rous sarcoma virus (RSV) and murine leukemia virus (MLV), flavivirideae: hepatitis C virus (HCV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), arenaviridae: lassa virus (LASV) and machupo virus (MACV), herpesviridae: kaposis sarcoma-associated herpesvirus (KSHV), rhabdoviridae: vesicular stomatitis virus (VSV), orthomyxoviridae: influenza A virus, paramyxoviridae: nipah virus, and coronaviridae: SARS-CoV.
References:
1. Neil, SJ. et al. (2008) Nature 451, 425-30. PMID: 18200009
2. Van Damme, N. et al. (2008) Cell host & microbe 3, 245-52. PMID: 18342597
3. Jouvenet, N. et al. (2009) Journal of virology 83, 1837-44. PMID: 19036818
4. Perez-Caballero, D. et al. (2009) Cell 139, 499-511. PMID: 19879838
5. Miyakawa, K. et al. (2009) PLoS pathogens 5, e1000700. PMID: 20019814
6. Hinz, A. et al. (2010) Cell host & microbe 7, 314-323. PMID: 20399176
7. Pardieu, C. et al. (2010) PLoS pathogens 6, e1000843. PMID: 20419159
8. Yang, H. et al. (2010) Proceedings of the National Academy of Sciences of the United States of America 107, 18428-32. PMID: 2094032
9. Xu, F. et al. (2011) Virology journal 8, 198. PMID: 21529378
10. Dafa-Berger, A. et al. (2012) Virology 428, 98-111. PMID: 22520941
Note: For research use only. Not suitable for clinical or therapeutic use.
Highlights:
• Research Grade — For PK/PD studies, assay development, and ADA research.
• Native Glycosylation — Mammalian expression ensures native-like patterns.
Host species: Human
Isotype: IgG
Species reactivity: Human
Immunogen:
Form: Liquid
Storage instructions:
Storage buffer: 0.01M PBS, pH7.4.
Concentration: 1mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: Research Grade Biosimilar
Target: Tetherin,Bonemarrowstromalantigen2,BST2,BST-2,CD317,HM1.24antigen
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: <1EU/mg, determined by LAL gel clotting assay
Expression system: Mammalian Cells
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names: XmAb-5592,XmAb5592,XmAb5592
Background: Bone marrow stromal antigen 2 (CD317/BST2) is a ~19 kDa protein. IFN-induced antiviral host restriction factor which efficiently blocks the release of diverse mammalian enveloped viruses by directly tethering nascent virions to the membranes of infected cells. Acts as a direct physical tether, holding virions to the cell membrane and linking virions to each other. The tethered virions can be internalized by endocytosis and subsequently degraded or they can remain on the cell surface. In either case, their spread as cell-free virions is restricted. Its target viruses belong to diverse families, including retroviridae: human immunodeficiency virus type 1 (HIV-1), human immunodeficiency virus type 2 (HIV-2), simian immunodeficiency viruses (SIVs), equine infectious anemia virus (EIAV), feline immunodeficiency virus (FIV), prototype foamy virus (PFV), Mason-Pfizer monkey virus (MPMV), human T-cell leukemia virus type 1 (HTLV-1), Rous sarcoma virus (RSV) and murine leukemia virus (MLV), flavivirideae: hepatitis C virus (HCV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), arenaviridae: lassa virus (LASV) and machupo virus (MACV), herpesviridae: kaposis sarcoma-associated herpesvirus (KSHV), rhabdoviridae: vesicular stomatitis virus (VSV), orthomyxoviridae: influenza A virus, paramyxoviridae: nipah virus, and coronaviridae: SARS-CoV.
References:
1. Neil, SJ. et al. (2008) Nature 451, 425-30. PMID: 18200009
2. Van Damme, N. et al. (2008) Cell host & microbe 3, 245-52. PMID: 18342597
3. Jouvenet, N. et al. (2009) Journal of virology 83, 1837-44. PMID: 19036818
4. Perez-Caballero, D. et al. (2009) Cell 139, 499-511. PMID: 19879838
5. Miyakawa, K. et al. (2009) PLoS pathogens 5, e1000700. PMID: 20019814
6. Hinz, A. et al. (2010) Cell host & microbe 7, 314-323. PMID: 20399176
7. Pardieu, C. et al. (2010) PLoS pathogens 6, e1000843. PMID: 20419159
8. Yang, H. et al. (2010) Proceedings of the National Academy of Sciences of the United States of America 107, 18428-32. PMID: 2094032
9. Xu, F. et al. (2011) Virology journal 8, 198. PMID: 21529378
10. Dafa-Berger, A. et al. (2012) Virology 428, 98-111. PMID: 22520941
Note: For research use only. Not suitable for clinical or therapeutic use.
Images
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SDS-PAGESDS-PAGE for Research Grade Anti-Human CD317/BST2 (XmAb 5592)
