Anti-Human CD105/ENG Reference Antibody (TRC205)
- Catalog number: BS11012
- Availability: In Stock
$370.00
- Ex Tax: $370.00
Description: Anti-Human CD105/ENG (TRC205) (BS11012) is a research-grade recombinant antibody targeting CD105. Produced in mammalian cells with native-like glycosylation.
Highlights:
• Research Grade — For PK/PD studies, assay development, and ADA research.
• Native Glycosylation — Mammalian expression ensures native-like patterns.
Host species: Human
Isotype: IgG
Species reactivity: Human
Immunogen:
Form: Liquid
Storage instructions:
Storage buffer: 0.01M PBS, pH7.4.
Concentration: 1mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: Research Grade Biosimilar
Target: CD105,END,Endoglin,ENG
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: <1EU/mg, determined by LAL gel clotting assay
Expression system: Mammalian Cells
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names: TRC205
Background: Endoglin (CD105/ENG) is a ~70 kDa protein. Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis. Required for normal structure and integrity of adult vasculature. Regulates the migration of vascular endothelial cells. Required for normal extraembryonic angiogenesis and for embryonic heart development. May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis.
References:
1. Castonguay, R. et al. (2011) The Journal of biological chemistry 286, 30034-46. PMID: 21737454
2. Nolan-Stevaux, O. et al. (2012) PloS one 7, e50920. PMID: 23300529
3. McAllister, KA. et al. (1994) Nature genetics 8, 345-51. PMID: 7894484
4. Lee, NY. et al. (2007) The Journal of biological chemistry 282, 21507-17. PMID: 17540773
5. Gougos, A. et al. (1990) The Journal of biological chemistry 265, 8361-4. PMID: 169283
6. Alt, A. et al. (2012) PloS one 7, e29948. PMID: 22347366
7. Bellón, T. et al. (1993) European journal of immunology 23, 2340-5. PMID: 8370410
Note: For research use only. Not suitable for clinical or therapeutic use.
Highlights:
• Research Grade — For PK/PD studies, assay development, and ADA research.
• Native Glycosylation — Mammalian expression ensures native-like patterns.
Host species: Human
Isotype: IgG
Species reactivity: Human
Immunogen:
Form: Liquid
Storage instructions:
Storage buffer: 0.01M PBS, pH7.4.
Concentration: 1mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: Research Grade Biosimilar
Target: CD105,END,Endoglin,ENG
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: <1EU/mg, determined by LAL gel clotting assay
Expression system: Mammalian Cells
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names: TRC205
Background: Endoglin (CD105/ENG) is a ~70 kDa protein. Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis. Required for normal structure and integrity of adult vasculature. Regulates the migration of vascular endothelial cells. Required for normal extraembryonic angiogenesis and for embryonic heart development. May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis.
References:
1. Castonguay, R. et al. (2011) The Journal of biological chemistry 286, 30034-46. PMID: 21737454
2. Nolan-Stevaux, O. et al. (2012) PloS one 7, e50920. PMID: 23300529
3. McAllister, KA. et al. (1994) Nature genetics 8, 345-51. PMID: 7894484
4. Lee, NY. et al. (2007) The Journal of biological chemistry 282, 21507-17. PMID: 17540773
5. Gougos, A. et al. (1990) The Journal of biological chemistry 265, 8361-4. PMID: 169283
6. Alt, A. et al. (2012) PloS one 7, e29948. PMID: 22347366
7. Bellón, T. et al. (1993) European journal of immunology 23, 2340-5. PMID: 8370410
Note: For research use only. Not suitable for clinical or therapeutic use.
Images
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SDS-PAGESDS-PAGE for Research Grade Anti-Human CD105/ENG (TRC205)
