Anti-PF4/CXCL4 Polyclonal Antibody
- Catalog number: PA10232
- Availability: In Stock
$168.00
- Ex Tax: $168.00
- Description: Anti-PF4/CXCL4 Polyclonal Antibody (PA10232) is a rabbit polyclonal antibody detecting CXCL4 in ELISA, IHC, WB. Suitable for Human.
Highlights:
• Affinity Purified — Minimal background and high purity for reliable results.
• Multi-Application — Validated across multiple applications. - Host species: Rabbit
- Species reactivity: Human
- Immunogen: E. coli - derived recombinant Human PF4/CXCL4 (Glu32-Ser101).
- Form: Liquid
- Storage buffer: 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
- Clonality: Polyclonal
- Isotype: IgG
- Applications: ELISA, IHC, WB
- Target: C-X-C motif chemokine 4,PF-4,Oncostatin-A,Endothelial cell growth inhibitor,CXCL4,Iroplact,Platelet factor 4,PF4,SCYB4
- Purification: Purified by antigen affinity column.
- Stability and Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
- Background: Platelet factor 4 (CXCL4/PF4) is a ~10 kDa protein. Chemokine released during platelet aggregation that plays a role in different biological processes including hematopoiesis, cell proliferation, differentiation, and activation. Acts via different functional receptors including CCR1, CXCR3A or CXCR3B. Upon interaction with CXCR3A receptor, induces activated T-lymphocytes migration mediated via downstream Ras/extracellular signal-regulated kinase (ERK) signaling. Neutralizes the anticoagulant effect of heparin by binding more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Plays a role in the inhibition of hematopoiesis and in the maintenance of hematopoietic stem cell (HSC) quiescence.
References:
1. Fox, JM. et al. (2018) Scientific reports 8, 9466. PMID: 29930254
2. Lecomte-Raclet, L. et al. (1998) Blood 91, 2772-80. PMID: 9531587
3. Mueller, A. et al. (2008) Journal of leukocyte biology 83, 875-82. PMID: 18174362
4. Van Raemdonck, K. et al. (2014) Angiogenesis 17, 631-40. PMID: 24469069
5. Yang, C. et al. (2022) Nature communications 13, 3426. PMID: 35701499
6. Affandi, AJ. et al. (2022) Cell reports 38, 110189. PMID: 34986347
7. Dudek, AZ. et al. (1997) The Journal of biological chemistry 272, 31785-92. PMID: 9395524 - Note: For research use only.
Images
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Western blotWestern blot analysis was performed using anti-PF4 polyclonal antibody at 1ug/mL on various samples.
Lane 1: Mouse spleen lysate
Lane 2: Mouse heart lysate
Datasheet
