Anti-Human IL-36Ra/IL-1F5 Reference Antibody (Spesolimab, RUO)
- Catalog number: BS10065
- Availability: In Stock
$176.00
- Ex Tax: $176.00
Description: Research Grade Spesolimab (BS10065) is a humanized monoclonal antibody detecting FIL1D in ELISA, Bioactivity: FACS, Functional assay, Research in vivo. Suitable for Human.
Highlights:
• Multi-Application — Validated across multiple applications.
Host species: Humanized
Isotype: IgG1-kappa
Species reactivity: Human
Immunogen:
Form: Liquid
Storage instructions:
Storage buffer: 0.01M PBS, pH7.4.
Concentration: 1mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: Research Grade Biosimilar
Target: FIL1D,Interleukin-1familymember5,IL-36Ra,IL1HY1,Interleukin-36receptorantagonistprotein,IL1RP3,IL-1RP3,IL-1rahomolog1,Interleukin-1-likeprotein1,IL-1-relatedprotein3,IL1L1,Interleukin-1HY1,IL-1HY1,Interleukin-1delta,FIL1delta,IL-1delta,IL-1L1,Interleukin-1receptorantagonisthomolog1,IL36RN,IL1F5,IL-1F5
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: <1EU/mg, determined by LAL gel clotting assay
Expression system: Mammalian Cells
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names: BI655130,BI655130,MAB92,CAS:2097104-58-8
Background: Interleukin-36 receptor antagonist protein (FIL1D,Interleukin-1 family member 5,IL-36Ra,IL1HY1,Interleukin-36 receptor antagonist protein,IL1RP3,IL-1RP3,IL-1ra homolog 1,Interleukin-1-like protein 1,IL-1-related protein 3,IL1L1,Interleukin-1 HY1,IL-1HY1,Interleukin-1 delta,FIL1 delta,IL-1 delta,IL-1L1,Interleukin-1 receptor antagonist homolog 1,IL36RN,IL1F5,IL-1F5) is a ~16 kDa protein. Inhibits the activity of interleukin-36 (IL36A,IL36B and IL36G) by binding to receptor IL1RL2 and preventing its association with the coreceptor IL1RAP for signaling. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor. Proposed to play a role in skin inflammation. May be involved in the innate immune response to fungal pathogens, such as Aspergillus fumigatus. May activate an anti-inflammatory signaling pathway by recruiting SIGIRR.
Note: For research use only. Not suitable for clinical or therapeutic use.
Highlights:
• Multi-Application — Validated across multiple applications.
Host species: Humanized
Isotype: IgG1-kappa
Species reactivity: Human
Immunogen:
Form: Liquid
Storage instructions:
Storage buffer: 0.01M PBS, pH7.4.
Concentration: 1mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: Research Grade Biosimilar
Target: FIL1D,Interleukin-1familymember5,IL-36Ra,IL1HY1,Interleukin-36receptorantagonistprotein,IL1RP3,IL-1RP3,IL-1rahomolog1,Interleukin-1-likeprotein1,IL-1-relatedprotein3,IL1L1,Interleukin-1HY1,IL-1HY1,Interleukin-1delta,FIL1delta,IL-1delta,IL-1L1,Interleukin-1receptorantagonisthomolog1,IL36RN,IL1F5,IL-1F5
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: <1EU/mg, determined by LAL gel clotting assay
Expression system: Mammalian Cells
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names: BI655130,BI655130,MAB92,CAS:2097104-58-8
Background: Interleukin-36 receptor antagonist protein (FIL1D,Interleukin-1 family member 5,IL-36Ra,IL1HY1,Interleukin-36 receptor antagonist protein,IL1RP3,IL-1RP3,IL-1ra homolog 1,Interleukin-1-like protein 1,IL-1-related protein 3,IL1L1,Interleukin-1 HY1,IL-1HY1,Interleukin-1 delta,FIL1 delta,IL-1 delta,IL-1L1,Interleukin-1 receptor antagonist homolog 1,IL36RN,IL1F5,IL-1F5) is a ~16 kDa protein. Inhibits the activity of interleukin-36 (IL36A,IL36B and IL36G) by binding to receptor IL1RL2 and preventing its association with the coreceptor IL1RAP for signaling. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor. Proposed to play a role in skin inflammation. May be involved in the innate immune response to fungal pathogens, such as Aspergillus fumigatus. May activate an anti-inflammatory signaling pathway by recruiting SIGIRR.
Note: For research use only. Not suitable for clinical or therapeutic use.
Images
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SDS-PAGESDS-PAGE for Research Grade Spesolimab.
