Anti-CD41/ITGA2B Polyclonal Antibody
- Catalog number: PA10350
- Availability: In Stock
$168.00
- Ex Tax: $168.00
- Description: Anti-CD41/ITGA2B Polyclonal Antibody (PA10350) is a rabbit polyclonal antibody detecting ITGA2B in ELISA, IHC, WB. Suitable for Human.
Highlights:
• Affinity Purified — Minimal background and high purity for reliable results.
• Multi-Application — Validated across multiple applications. - Host species: Rabbit
- Species reactivity: Human, Mouse
- Immunogen: E. coli - derived recombinant Human CD41/ITGA2B (Ala678-Leu894).
- Form: Liquid
- Storage buffer: 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
- Clonality: Polyclonal
- Isotype: IgG
- Applications: ELISA, IHC, WB
- Target: CD41,ITGAB,GPIIb,ITGA2B,Platelet membrane glycoprotein IIb,GP2B,Integrin alpha-IIb,GPalpha IIb
- Purification: Purified by antigen affinity column.
- Stability and Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
- Background: Integrin alpha-IIb (CD41/ITGA2B) is a ~113 kDa protein. Integrin alpha-IIb/beta-3 (ITGA2B:ITGB3) is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.
References:
1. Si-Tahar, M. et al. (1997) The Journal of biological chemistry 272, 11636-47. PMID: 9111081
2. Hermand, P. et al. (2003) The Journal of biological chemistry 278, 4892-8. PMID: 12477717 - Note: For research use only.
Images
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Western blotWestern blot analysis was performed using anti-ITGA2B polyclonal antibody at 1ug/mL on various samples.
Lane 1: Mouse spleen lysate
Lane 2: Mouse lung lysate
Lane 3: Rat spleen lysate
Lane 4: Rat lung lysate
Datasheet
