Anti-CAPN2 Polyclonal Antibody
- Catalog number: PA10530
- Availability: In Stock
$168.00
- Ex Tax: $168.00
- Description: Anti-CAPN2 Polyclonal Antibody (PA10530) is a rabbit polyclonal antibody detecting CAPN2 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Bovine, and Macaca fascicularis.
Highlights:
• Affinity Purified — Minimal background and high purity for reliable results.
• Multi-Application — Validated across multiple applications.
• Multi-Species — Cross-reactive for translational research. - Host species: Rabbit
- Species reactivity: Human, Mouse, Rat
- Immunogen: E. coli - derived recombinant Human CAPN2 (Leu45-Asp514).
- Form: Liquid
- Storage buffer: 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
- Clonality: Polyclonal
- Isotype: IgG
- Applications: ELISA, IHC, WB
- Target: Calpain M-type,Calcium-activated neutral proteinase 2,CANPL2,Calpain-2 catalytic subunit,CAPN2,Calpain large polypeptide L2,Calpain-2 large subunit,Millimolar-calpain,M-calpain,CANP 2
- Purification: Purified by antigen affinity column.
- Stability and Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
- Background: Calpain-2 catalytic subunit (CAPN2) is a ~79 kDa protein. Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at 'Arg-226'. Proteolytically cleaves CPEB3 following neuronal stimulation which abolishes CPEB3 translational repressor activity, leading to translation of CPEB3 target mRNAs.
References:
1. Sánchez-Sánchez, F. et al. (2007) The Journal of biological chemistry 282, 27810-24. PMID: 17650508 - Note: For research use only.
Images
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Western blotWestern blot analysis was performed using anti-CAPN2 polyclonal antibody at 1ug/mL on various samples.
Lane 1: MDA-MB-231 cell lysate
Lane 2: A549 cell lysate
Lane 3: K562 cell lysate
Lane 4: C2C12 cell lysate
Lane 5: PC-3 cell lysate
Lane 6: PC-12 cell lysate
Lane 7: U2OS cell lysate
Datasheet
