Anti-BMP6 Polyclonal Antibody
- Catalog number: PA10592
- Availability: In Stock
$168.00
- Ex Tax: $168.00
- Description: Anti-BMP6 Polyclonal Antibody (PA10592) is a rabbit polyclonal antibody detecting BMP6 in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.
Highlights:
• Affinity Purified — Minimal background and high purity for reliable results.
• Multi-Application — Validated across multiple applications.
• Multi-Species — Cross-reactive for translational research. - Host species: Rabbit
- Species reactivity: Human, Mouse, Rat
- Immunogen: E. coli - derived recombinant Human BMP6 (Ser375-His513).
- Form: Liquid
- Storage buffer: 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
- Clonality: Polyclonal
- Isotype: IgG
- Applications: ELISA, IHC, WB
- Target: VG-1-R,VG-1-related protein,Bone morphogenetic protein 6,VGR-1,BMP-6,VGR,BMP6
- Purification: Purified by antigen affinity column.
- Stability and Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
- Background: Bone morphogenetic protein 6 (BMP6) is a ~57 kDa protein. Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes including cartilage and bone formation. Also plays an important role in the regulation of HAMP/hepcidin expression and iron metabolism by acting as a ligand for hemojuvelin/HJV. Also acts to promote expression of HAMP, potentially via the interaction with its receptor BMPR1A/ALK3. Initiates the canonical BMP signaling cascade by associating with type I receptor ACVR1 and type II receptor ACVR2B. In turn, ACVR1 propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target.
References:
1. Seeherman, HJ. et al. (2019) Science translational medicine 11. PMID: 31019025
2. Daher, R. et al. (2016) Gastroenterology 150, 672-683.e4. PMID: 26582087
3. Arezes, J. et al. (2018) Blood 132, 1473-1477. PMID: 30097509
4. Wang, CY. et al. (2020) Blood 135, 453-456. PMID: 31800957
5. Saremba, S. et al. (2008) The FEBS journal 275, 172-83. PMID: 18070108
6. Pulkkinen, HH. et al. (2021) Angiogenesis 24, 129-144. PMID: 33021694 - Note: For research use only.
Images
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Western blotWestern blot analysis was performed using anti-BMP6 polyclonal antibody at 1ug/mL on various samples.
Lane 1: Mouse heart lysate
Datasheet
