Anti-STAT3 Polyclonal Antibody
- Catalog number: PA10758
- Availability: In Stock
$168.00
- Ex Tax: $168.00
- Description: Anti-STAT3 Polyclonal Antibody (PA10758) is a rabbit polyclonal antibody detecting STAT3 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Bovine, and Chicken.
Highlights:
• Affinity Purified — Minimal background and high purity for reliable results.
• Multi-Application — Validated across multiple applications.
• Multi-Species — Cross-reactive for translational research. - Host species: Rabbit
- Species reactivity: Human, Mouse, Rat
- Immunogen: E. coli - derived recombinant Human STAT3 (Met1-Met770).
- Form: Liquid
- Storage buffer: 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
- Clonality: Polyclonal
- Isotype: IgG
- Applications: ELISA, IHC, WB
- Target: Signal transducer and activator of transcription 3,APRF,STAT3,Acute-phase response factor
- Purification: Purified by antigen affinity column.
- Stability and Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
- Background: Signal transducer and activator of transcription 3 (STAT3) is a ~88 kDa protein. Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Upon activation of IL6ST/gp130 signaling by interleukin-6 (IL6), binds to the IL6-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA.
References:
1. Tsai, YT. et al. (2000) Molecular and cellular biology 20, 2043-54. PMID: 10688651
2. Yamamoto, T. et al. (2002) Biochemical and biophysical research communications 297, 811-7. PMID: 12359225
3. Shao, H. et al. (2003) Cancer research 63, 3923-30. PMID: 12873986
4. Dreuw, A. et al. (2004) The Journal of biological chemistry 279, 36112-20. PMID: 1519470
5. Yuan, ZL. et al. (2005) Science (New York, N.Y.) 307, 269-73. PMID: 15653507
6. Ray, S. et al. (2005) Gastroenterology 129, 1616-32. PMID: 1628596
7. Saxena, NK. et al. (2007) The Journal of biological chemistry 282, 13316-25. PMID: 17344214
8. Jiang, H. et al. (2008) Biochemical and biophysical research communications 368, 1-5. PMID: 1824258
9. Hou, T. et al. (2008) The Journal of biological chemistry 283, 30725-34. PMID: 18782771
10. Gao, X. et al. (2012) Molecular cell 45, 598-609. PMID: 22306293 - Note: For research use only.
Images
-
Western blotWestern blot analysis was performed using anti-STAT3 polyclonal antibody at 1ug/mL on various samples.
Lane 1: Hela cell lysate
Lane 2: A549 cell lysate
Lane 3: A431 cell lysate
Lane 4: 293T cell lysate
Datasheet
