Anti-HDAC1 Polyclonal Antibody
- Catalog number: PA11048
- Availability: In Stock
$168.00
- Ex Tax: $168.00
- Description: Anti-HDAC1 Polyclonal Antibody (PA11048) is a rabbit polyclonal antibody detecting HDAC1 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Bovine, and Chicken.
Highlights:
• Affinity Purified — Minimal background and high purity for reliable results.
• Multi-Application — Validated across multiple applications.
• Multi-Species — Cross-reactive for translational research. - Host species: Rabbit
- Species reactivity: Human, Mouse, Rat
- Immunogen: E. coli - derived recombinant Human HDAC1 (Val183-Ala482).
- Form: Liquid
- Storage buffer: 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
- Clonality: Polyclonal
- Isotype: IgG
- Applications: ELISA, IHC, WB
- Target: Histone deacetylase 1,HDAC1,RPD3L1,HD1
- Purification: Purified by antigen affinity column.
- Stability and Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
- Background: Histone deacetylase 1 (HDAC1) is a ~55 kDa protein. Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin. As part of the SIN3B complex is recruited downstream of the constitutively active genes transcriptional start sites through interaction with histones and mitigates histone acetylation and RNA polymerase II progression within transcribed regions contributing to the regulation of transcription.
References:
1. Qiu, Y. et al. (2006) Molecular cell 22, 669-79. PMID: 16762839
2. Wang, C. et al. (2007) The Journal of biological chemistry 282, 29902-9. PMID: 17704056
3. Wei, W. et al. (2017) Cell research 27, 898-915. PMID: 2849781
4. Le Guezennec, X. et al. (2006) Molecular and cellular biology 26, 843-51. PMID: 1642844
5. Hoffmeister, H. et al. (2017) Nucleic acids research 45, 10534-10554. PMID: 28977666
6. Jelinic, P. et al. (2011) Molecular and cellular biology 31, 54-62. PMID: 21041482
7. Ray, S. et al. (2005) Gastroenterology 129, 1616-32. PMID: 16285960
8. Zheng, G. et al. (2006) Biochemical and biophysical research communications 339, 1069-75. PMID: 16337145
9. Hung, JJ. et al. (2006) Molecular and cellular biology 26, 1770-85. PMID: 16478997 - Note: For research use only.
Images
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Western blotWestern blot analysis was performed using anti-HDAC1 polyclonal antibody at 1ug/mL on various samples.
Lane 1: K562 cell lysate
Lane 2: Jurkat cell lysate
Lane 3: HepG2 cell lysate
Datasheet
