Anti-IL36A/IL-1F6 Polyclonal Antibody
- Catalog number: PA11386
- Availability: In Stock
$168.00
- Ex Tax: $168.00
- Description: Anti-IL36A/IL-1F6 Polyclonal Antibody (PA11386) is a rabbit polyclonal antibody detecting IL-1F6 in ELISA, IHC, WB. Suitable for Human.
Highlights:
• Affinity Purified — Minimal background and high purity for reliable results.
• Multi-Application — Validated across multiple applications. - Host species: Rabbit
- Species reactivity: Human
- Immunogen: E. coli - derived recombinant Human IL36A/IL-1F6 (Met1-Phe158).
- Form: Liquid
- Storage buffer: 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
- Clonality: Polyclonal
- Isotype: IgG
- Applications: ELISA, IHC, WB
- Target: IL1F6,IL-1 epsilon,IL1E,IL36A,Interleukin-1 family member 6,FIL1 epsilon,FIL1E,IL-1F6,Interleukin-36 alpha,Interleukin-1 epsilon
- Purification: Purified by antigen affinity column.
- Stability and Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
- Background: Interleukin-36 alpha (IL36A/IL-1F6) is a ~17 kDa protein. Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T-cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1, and the production of pro-inflammatory cytokines such as TNF, IL-8 and IL-6. In cultured monocytes up-regulates expression of IL-1A, IL-1B and IL-6.
- Note: For research use only.
Images
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Western blotWestern blot analysis was performed using anti-IL36A polyclonal antibody at 1μg/ml on various samples.
Lane 1: MDA-MB-231 cell lysate
Lane 2: MCF7 cell lysate
Lane 3: Mouse lung lysate
Lane 4: Rat brian lysate
Lane 5: Rat lung lysate
