Research Grade Asunercept

Description: Asunercept (BS11216) is a research-grade recombinant antibody targeting CD178. Produced in mammalian cells with native-like glycosylation.
Highlights:
• Research Grade — For PK/PD studies, assay development, and ADA research.
• Native Glycosylation — Mammalian expression ensures native-like patterns.
Host species:
Isotype: Fusion-[FAS(Fascellsurfacedeathreceptor,TNFRSF6,tumornecrosisfactorreceptor(TNFR)superfamilymember6,FAS1,APO-1,CD95)]2-IGHG1Fc(Fragmentconstant)
Species reactivity: Human
Immunogen:
Form: Liquid
Storage instructions:
Storage buffer: 0.01M PBS, pH7.4.
Concentration: 1mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality:
Applications: Research Grade Biosimilar
Target: Receptor-bindingFasLectodomain,APL,APT1LG1,FasLICD,Fasantigenligand,CD178,sFasL,CD95L,APTL,TNFSF6,Apoptosisantigenligand,SPA,FASLG,FasL,SPPL2A-processedFasLform,Tumornecrosisfactorligandsuperfamilymember6,SolubleFasligand,Fasligand,CD95ligand,CD95-L,FASL
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: <1EU/mg, determined by LAL gel clotting assay
Expression system: Mammalian Cells
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names: APG-101,CAS:1450882-18-4
Background: Tumor necrosis factor ligand superfamily member 6 (CD178/FASLG) is a ~31 kDa protein. Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. Involved in cytotoxic T-cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development. Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses. TNFRSF6/FAS-mediated apoptosis also has a role in the induction of peripheral tolerance. Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis.
References:
1. Ruiz-García, R. et al. (2015) Pediatric research 78, 603-8. PMID: 26334989
2. Schneider, P. et al. (1997) The Journal of biological chemistry 272, 18827-33. PMID: 9228058
3. Alderson, MR. et al. (1995) The Journal of experimental medicine 181, 71-7. PMID: 752878
4. Tanaka, M. et al. (1998) Nature medicine 4, 31-6. PMID: 9427603
5. Liu, W. et al. (2016) Structure (London, England : 1993) 24, 2016-2023. PMID: 27806260
Note: For research use only. Not suitable for clinical or therapeutic use.