Anti-TGM2 Polyclonal Antibody
- Catalog number: PA11507
- Availability: In Stock
$168.00
- Ex Tax: $168.00
- Description: Anti-TGM2 Polyclonal Antibody (PA11507) is a rabbit polyclonal antibody detecting TGM2 in ELISA, IHC, WB. Suitable for Human, Mouse, and Bovine.
Highlights:
• Affinity Purified — Minimal background and high purity for reliable results.
• Multi-Application — Validated across multiple applications.
• Multi-Species — Cross-reactive for translational research. - Host species: Rabbit
- Species reactivity: Human, Mouse, Rat
- Immunogen: E. coli - derived recombinant Human TGM2 (Met1-Ser538).
- Form: Liquid
- Storage buffer: 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
- Clonality: Polyclonal
- Isotype: IgG
- Applications: ELISA, IHC, WB
- Target: Protein-glutamine deamidase TGM2,TGase II,Heart G alpha(h),Erythrocyte transglutaminase,Protein-glutamine gamma-glutamyltransferase 2,TG(C),Transglutaminase C,Protein-glutamine serotonyltransferase TGM2,tTG,tTgase,Transglutaminase-2,Protein-glutamine noradrenalinyltransferase TGM2,TGM2,TG2,TGase C,Protein G alpha(h),Protein-glutamine histaminyltransferase TGM2,Tissue transglutaminase,hhG alpha(h),G(h),hTG2,Transglutaminase H,Protein-glutamine dopaminyltransferase TGM2,TGC,Isopeptidase TGM2,TGase-2,TGase H,Transglutaminase II
- Purification: Purified by antigen affinity column.
- Stability and Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
- Background: Protein-glutamine gamma-glutamyltransferase 2 (TGM2) is a ~77 kDa protein. Calcium-dependent acyltransferase that catalyzes the formation of covalent bonds between peptide-bound glutamine and various primary amines, such as gamma-amino group of peptide-bound lysine, or mono- and polyamines, thereby producing cross-linked or aminated proteins, respectively. Involved in many biological processes, such as bone development, angiogenesis, wound healing, cellular differentiation, chromatin modification and apoptosis. Acts as a protein-glutamine gamma-glutamyltransferase by mediating the cross-linking of proteins, such as ACO2, HSPB6, FN1, HMGB1, RAP1GDS1, SLC25A4/ANT1, SPP1 and WDR54. Under physiological conditions, the protein cross-linking activity is inhibited by GTP; inhibition is relieved by Ca(2+) in response to various stresses. When secreted, catalyzes cross-linking of proteins of the extracellular matrix, such as FN1 and SPP1 resulting in the formation of scaffolds.
References:
1. Kanchan, K. et al. (2013) The Biochemical journal 455, 261-72. PMID: 23941696
2. Jeong, EM. et al. (2020) International journal of molecular sciences 21. PMID: 31991788
3. Nemes, Z. et al. (1997) The Journal of biological chemistry 272, 20577-83. PMID: 9252372
4. Upchurch, HF. et al. (1991) Journal of cellular physiology 149, 375-82. PMID: 1683874
5. Lai, TS. et al. (2017) Amino acids 49, 501-515. PMID: 27270573
6. Hernandez-Fernaud, JR. et al. (2017) Nature communications 8, 14206. PMID: 2819836
7. Melino, G. et al. (1994) Molecular and cellular biology 14, 6584-96. PMID: 7935379
8. Hsieh, YF. et al. (2013) PloS one 8, e81516. PMID: 24349085 - Note: For research use only.
Images
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Western blotWestern blot analysis was performed using anti-TGM2 polyclonal antibody at 1ug/mL on various samples.
Lane 1: HUVEC cell lysate
Lane 2: BxPC-3 cell lysate
Lane 3: A549 cell lysate
Datasheet
