Anti-Human GSDMD Polyclonal Antibody
- Catalog number: PA11572
- Availability: In Stock
$168.00
- Ex Tax: $168.00
- Description: Anti-Human GSDMD Polyclonal Antibody (PA11572) is a rabbit polyclonal antibody detecting GSDMD in ELISA, IHC, WB. Suitable for Human.
Highlights:
• Affinity Purified — Minimal background and high purity for reliable results.
• Multi-Application — Validated across multiple applications. - Host species: Rabbit
- Species reactivity: Human
- Immunogen: E. coli - derived recombinant Human GSDMD (Pro278-His484).
- Form: Liquid
- Storage buffer: 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
- Clonality: Polyclonal
- Isotype: IgG
- Applications: ELISA, IHC, WB
- Target: GSDMD-CT, hGSDMD-NTD, Gasdermin domain-containing protein 1, Gasdermin-D, DFNA5L, GSDMD-NT, hGSDMD-CTD, GSDMDC1, GSDMD
- Purification: Purified by antigen affinity column.
- Stability and Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
- Background: Gasdermin-D (GSDMD) is a ~52 kDa protein. Precursor of a pore-forming protein that plays a key role in host defense against pathogen infection and danger signals. This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-D, N-terminal) binds to membranes and forms pores, triggering pyroptosis.
References:
1. Shi, J. et al. (2015) Nature 526, 660-5. PMID: 26375003
2. Kayagaki, N. et al. (2015) Nature 526, 666-71. PMID: 26375259
3. Ding, J. et al. (2016) Nature 535, 111-6. PMID: 27281216 - Note: For research use only.
Images
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Western blotWestern blot analysis was performed using anti-GSDMD polyclonal antibody at 1ug/mL on various samples.
Lane 1: Jurkat cell lysate
Lane 2: THP-1 cell lysate
Datasheet
