Anti-CD49f/ITGA6 Polyclonal Antibody
- Catalog number: PA11651
- Availability: In Stock
$168.00
- Ex Tax: $168.00
- Description: Anti-CD49f/ITGA6 Polyclonal Antibody (PA11651) is a rabbit polyclonal antibody detecting ITGA6 in ELISA, IHC, WB. Suitable for Human and Mouse.
Highlights:
• Affinity Purified — Minimal background and high purity for reliable results.
• Multi-Application — Validated across multiple applications. - Host species: Rabbit
- Species reactivity: Human, Mouse, Rat
- Immunogen: E. coli - derived recombinant Human CD49f/ITGA6 (Ala23-Gln462).
- Form: Liquid
- Storage buffer: 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
- Clonality: Polyclonal
- Isotype: IgG
- Applications: ELISA, IHC, WB
- Target: CD49 antigen-like family member F, Integrin alpha-6, ITGA6, VLA-6, CD49f, Alpha6p
- Purification: Purified by antigen affinity column.
- Stability and Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
- Background: Integrin alpha-6 (CD49f/ITGA6) is a ~126 kDa protein. Integrin alpha-6/beta-1 (ITGA6:ITGB1) is a receptor for laminin on platelets. Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion. Integrin alpha-6/beta-4 (ITGA6:ITGB4) is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling.
References:
1. Ieguchi, K. et al. (2010) The Journal of biological chemistry 285, 31388-98. PMID: 20682778
2. Fujita, M. et al. (2012) The Journal of biological chemistry 287, 12491-500. PMID: 2235176
3. Cedano Prieto, DM. et al. (2017) PloS one 12, e0184285. PMID: 28873464 - Note: For research use only.
Images
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Western blotWestern blot analysis was performed using anti-CD49f/ITGA6 polyclonal antibody at 1ug/mL on recombinant CD49f/ITGA6 (Catalog No. PH13772).
Datasheet
