Anti-Human IGF2BP1 Polyclonal Antibody
- Catalog number: PA11895
- Availability: In Stock
$168.00
- Ex Tax: $168.00
- Description: Anti-Human IGF2BP1 Polyclonal Antibody (PA11895) is a rabbit polyclonal antibody detecting IGF2BP1 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Danio rerio, and Chicken.
Highlights:
• Affinity Purified — Minimal background and high purity for reliable results.
• Multi-Application — Validated across multiple applications.
• Multi-Species — Cross-reactive for translational research. - Host species: Rabbit
- Species reactivity: Human
- Immunogen: E. coli - derived recombinant Human IGF2BP1 (Val194-Asn369).
- Form: Liquid
- Storage buffer: 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
- Clonality: Polyclonal
- Isotype: IgG
- Applications: ELISA, IHC, WB
- Target: VICKZ family member 1, Zipcode-binding protein 1, IGF2BP1, VICKZ1, Coding region determinant-binding protein, IMP1, IMP-1, ZBP1, IGF-II mRNA-binding protein 1, CRDBP, Insulin-like growth factor 2 mRNA-binding protein 1, ZBP-1, CRD-BP, IGF2 mRNA-binding protein 1
- Purification: Purified by antigen affinity column.
- Stability and Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
- Background: Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) is a ~63 kDa protein. RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Preferentially binds to N6-methyladenosine (m6A)-containing mRNAs and increases their stability. Plays a direct role in the transport and translation of transcripts required for axonal regeneration in adult sensory neurons.
References:
1. Huang, H. et al. (2018) Nature cell biology 20, 285-295. PMID: 29476152
2. Zhu, S. et al. (2020) Nature communications 11, 1685. PMID: 32245947 - Note: For research use only.
Images
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Western blotWestern blot analysis was performed using anti-IGF2BP1 polyclonal antibody at 1μg/ml on various samples.
Lane 1: K562 cell lysate
Lane 2: 293T cell lysate
