Anti-Human YWHAE Polyclonal Antibody
- Catalog number: PA11959
- Availability: In Stock
$168.00
- Ex Tax: $168.00
- Description: Anti-Human YWHAE Polyclonal Antibody (PA11959) is a rabbit polyclonal antibody detecting YWHAE in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Bovine, and Chicken.
Highlights:
• Affinity Purified — Minimal background and high purity for reliable results.
• Multi-Application — Validated across multiple applications.
• Multi-Species — Cross-reactive for translational research. - Host species: Rabbit
- Species reactivity: Human
- Immunogen: E. coli - derived recombinant Human YWHAE (Met1-Gln255).
- Form: Liquid
- Storage buffer: 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
- Clonality: Polyclonal
- Isotype: IgG
- Applications: ELISA, IHC, WB
- Target: 14-3-3E, YWHAE, 14-3-3 protein epsilon
- Purification: Purified by antigen affinity column.
- Stability and Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
- Background: 14-3-3 protein epsilon (YWHAE) is a ~29 kDa protein. Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Positively regulates phosphorylated protein HSF1 nuclear export to the cytoplasm. Plays a positive role in the antiviral signaling pathway upstream of TBK1 via interaction with RIGI.
References:
1. Okamoto, Y. et al. (2011) The Journal of biological chemistry 286, 7171-81. PMID: 2118925
2. Zhang, ZD. et al. (2022) Advanced science (Weinheim, Baden-Wurttemberg, Germany) 9, e2105391. PMID: 35343654
3. Wang, X. et al. (2003) Molecular and cellular biology 23, 6013-26. PMID: 12917326
4. Andrews, DDT. et al. (2023) Journal of virology 97, e0060423. PMID: 37555661
5. Liu, HM. et al. (2012) Cell host & microbe 11, 528-37. PMID: 22607805
6. Guo, M. et al. (2023) Cancer biology & therapy 24, 2246203. PMID: 37599448 - Note: For research use only.
Images
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Western blotWestern blot analysis was performed using anti-YWHAE polyclonal antibody at 1μg/ml on various samples.
Lane 1: Hela cell lysate
Lane 2: MCF-7 cell lysate
Lane 3: Jurkat cell lysate
Lane 4: NIH3T3 cell lysate
Lane 5: RAW264.7 cell lysate
Lane 6: A375 cell lysate
Lane 7: 293T cell lysate
Datasheet
