Anti-Human ATP1B1 Polyclonal Antibody
- Catalog number: PA12087
- Availability: In Stock
$168.00
- Ex Tax: $168.00
- Host species: Rabbit
- Species reactivity: Human
- Immunogen: E. coli - derived recombinant Human ATP1B1 (Gly76-Ser303).
- Form: Liquid
- Storage buffer: 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
- Clonality: Polyclonal
- Isotype: IgG
- Applications: ELISA, IHC, WB
- Target: Sodium/potassium-transporting ATPase subunit beta-1, ATP1B1, Sodium/potassium-dependent ATPase subunit beta-1, ATP1B
- Purification: Purified by antigen affinity column.
- Stability and Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
- Background: Sodium/potassium-transporting ATPase subunit beta-1 (ATP1B1) is a ~35 kDa protein. This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. Plays a role in innate immunity by enhancing virus-triggered induction of interferons (IFNs) and interferon stimulated genes (ISGs). Mechanistically, enhances the ubiquitination of TRAF3 and TRAF6 as well as the phosphorylation of TAK1 and TBK1.
References:
1. Bab-Dinitz, E. et al. (2009) Biochemistry 48, 8684-91. PMID: 19694409
2. Cao, W. et al. (2021) Journal of immunology (Baltimore, Md. : 1950) 206, 2668-2681. PMID: 34011520 - Note: For research use only.
Images
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Western blotWestern blot analysis was performed using anti-ATP1B1 polyclonal antibody at 1μg/ml on various samples.
Lane 1: Mouse brain lysate
Lane 2: Rat brain lysate
