Anti-Human NDEL1 Polyclonal Antibody
- Catalog number: PA12248
- Availability: In Stock
$168.00
- Ex Tax: $168.00
- Host species: Rabbit
- Species reactivity: Human
- Immunogen: E. coli - derived recombinant Human NDEL1 (Asp8-Lys193).
- Form: Liquid
- Storage buffer: 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
- Clonality: Polyclonal
- Isotype: IgG
- Applications: ELISA, IHC, WB
- Target: Protein Nudel, EOPA, Nuclear distribution protein nudE-like 1, NUDEL, MITAP1, NDEL1, Mitosin-associated protein 1
- Purification: Purified by antigen affinity column.
- Stability and Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
- Background: Nuclear distribution protein nudE-like 1 (NDEL1) is a ~38 kDa protein. Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripetal motion of secretory vesicles and the coupling of the nucleus and centrosome.
References:
1. Zhang, Y. et al. (2022) Structure (London, England : 1993) 30, 386-395.e5. PMID: 34793709 - Note: For research use only.
Images
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Western blotWestern blot analysis was performed using anti-NDEL1 polyclonal antibody at 1μg/ml on various samples.
Lane 1: Mouse brain lysate
Lane 2: Rat brain lysate
Datasheet
