Anti-Human TUFM Polyclonal Antibody

Size

50 µg

100 µg (+$110.00)

Qty

Host species: Rabbit
Species reactivity: Human
Immunogen: E. coli - derived recombinant Human TUFM (Asp67-Gly452).
Form: Liquid
Storage buffer: 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Clonality: Polyclonal
Isotype: IgG
Applications: ELISA, IHC, WB
Target: P43, Elongation factor Tu, mitochondrial, TUFM, EF-Tu
Purification: Purified by antigen affinity column.
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background: Elongation factor Tu, mitochondrial (TUFM) is a ~49 kDa protein. GTP hydrolase that promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Participates in mitochondrial translation. Also plays a role in the regulation of autophagy and innate immunity. Recruits ATG5-ATG12 and NLRX1 at mitochondria and serves as a checkpoint of the RIGI-MAVS pathway. In turn, inhibits RLR-mediated type I interferon while promoting autophagy.
References:
1. Lei, Y. et al. (2012) Immunity 36, 933-46. PMID: 22749352
2. Ding, B. et al. (2017) Cell host & microbe 21, 538-547.e4. PMID: 28407488
Note: For research use only.

Datasheet

$168.00