Anti-CD29/ITGB1 Polyclonal Antibody
- Catalog number: PA12467
- Availability: In Stock
$168.00
- Ex Tax: $168.00
- Host species: Rabbit
- Species reactivity: Human, Mouse, Rat
- Immunogen: E. coli - derived recombinant Human CD29/ITGB1 (Ser86-Ile461).
- Form: Liquid
- Storage buffer: 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
- Clonality: Polyclonal
- Isotype: IgG
- Applications: ELISA, IHC, WB
- Target: MSK12, VLA-4 subunit beta, CD29, Integrin beta-1, ITGB1, FNRB, MDF2, GPIIA, Glycoprotein IIa, Fibronectin receptor subunit beta
- Purification: Purified by antigen affinity column.
- Stability and Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
- Background: Integrin beta-1 (CD29/ITGB1) is a ~88 kDa protein. Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen.
References:
1. Fujita, M. et al. (2012) Journal of immunology (Baltimore, Md. : 1950) 189, 5809-19. PMID: 23125415
2. Fujita, M. et al. (2014) PloS one 9, e96372. PMID: 24789099
3. Saegusa, J. et al. (2008) The Journal of biological chemistry 283, 26107-15. PMID: 18635536
4. Fujita, M. et al. (2015) The Journal of biological chemistry 290, 259-71. PMID: 25398877
5. Bax, DV. et al. (2003) The Journal of biological chemistry 278, 34605-16. PMID: 12807887
6. Jovanovic, J. et al. (2007) The Journal of biological chemistry 282, 6743-51. PMID: 17158881
7. Schumacher, S. et al. (2021) Science advances 7. PMID: 33962943
8. Takada, YK. et al. (2017) The Journal of biological chemistry 292, 20067-20075. PMID: 2903043
9. Takada, YK. et al. (2019) Journal of immunology (Baltimore, Md. : 1950) 203, 1383-1391. PMID: 31331973
10. Morris, GE. et al. (2022) British journal of pharmacology 179, 4958-4973. PMID: 35802072 - Note: For research use only.
Images
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Western blotWestern blot analysis was performed using anti-CD29/ITGB1 polyclonal antibody at 1ug/mL on recombinant CD29/ITGB1 (Catalog No. PH14544).
Datasheet
