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Anti-Human SNX1 Polyclonal Antibody

Anti-Human SNX1 Polyclonal Antibody

  • Catalog number: PA12469
  • Availability: In Stock

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  • $168.00

  • Ex Tax: $168.00

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  • Host species: Rabbit
  • Species reactivity: Human
  • Immunogen: E. coli - derived recombinant Human SNX1 (Phe143-Ser522).
  • Form: Liquid
  • Storage buffer: 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
  • Clonality: Polyclonal
  • Isotype: IgG
  • Applications: ELISA, IHC, WB
  • Target: Sorting nexin-1, SNX1
  • Purification: Purified by antigen affinity column.
  • Stability and Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
  • Background: Sorting nexin-1 (SNX1) is a ~59 kDa protein. Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable).
    References:
    1. Cozier, GE. et al. (2002) The Journal of biological chemistry 277, 48730-6. PMID: 12198132
    2. Bhatia, VK. et al. (2009) The EMBO journal 28, 3303-14. PMID: 19816406
    3. van Weering, JR. et al. (2012) The EMBO journal 31, 4466-80. PMID: 23085988
    4. Carlton, J. et al. (2004) Current biology : CB 14, 1791-800. PMID: 15498486
    5. Rojas, R. et al. (2007) Molecular and cellular biology 27, 1112-24. PMID: 17101778
    6. Bujny, MV. et al. (2007) Journal of cell science 120, 2010-21. PMID: 1755097
    7. Mari, M. et al. (2008) Traffic (Copenhagen, Denmark) 9, 380-93. PMID: 18088323
    8. Kim, E. et al. (2010) Biochemical and biophysical research communications 403, 167-71. PMID: 21040701
    9. Gullapalli, A. et al. (2006) Molecular biology of the cell 17, 1228-38. PMID: 16407403
  • Note: For research use only.

Images

  • Western blot for Anti-Human SNX1 Polyclonal Antibody
    Western blot

    Western blot analysis was performed using anti-SNX1 polyclonal antibody at 1μg/ml on various samples.
    Lane 1: U87 cell lysate
    Lane 2: DU145 cell lysate

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