Anti-Human USP22 Polyclonal Antibody
- Catalog number: PA12670
- Availability: In Stock
$168.00
- Ex Tax: $168.00
- Host species: Rabbit
- Species reactivity: Human
- Immunogen: E. coli - derived recombinant Human USP22 (Gly182-Glu525).
- Form: Liquid
- Storage buffer: 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
- Clonality: Polyclonal
- Isotype: IgG
- Applications: ELISA, IHC, WB
- Target: Deubiquitinating enzyme 22, USP22, Ubiquitin thioesterase 22, Ubiquitin carboxyl-terminal hydrolase 22, KIAA1063, USP3L, Ubiquitin-specific-processing protease 22
- Purification: Purified by antigen affinity column.
- Stability and Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
- Background: Ubiquitin carboxyl-terminal hydrolase 22 (USP22) is a ~59 kDa protein. Deubiquitinase that plays a role in several cellular processes including transcriptional regulation, cell cycle progression or innate immunity. As part of the transcription regulatory histone acetylation (HAT) complex SAGA, catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a transcriptional coactivator. Recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Facilitates cell-cycle progression by stabilizing CCNB1 and antagonizing its proteasome-mediated degradation in a cell cycle-specific manner. Modulates cell cycle progression and apoptosis also by antagonizing TP53 transcriptional activation through deacetylase SIRT1 stabilization.
References:
1. Zhao, Y. et al. (2008) Molecular cell 29, 92-101. PMID: 18206972
2. Zhang, XY. et al. (2008) Molecular cell 29, 102-11. PMID: 18206973
3. Zhang, XY. et al. (2008) Cell cycle (Georgetown, Tex.) 7, 1522-4. PMID: 18469533
4. Lin, Z. et al. (2015) Cell discovery 1, 15028-. PMID: 27030811
5. Lin, Z. et al. (2012) Molecular cell 46, 484-94. PMID: 22542455
6. Cai, Z. et al. (2020) The Journal of experimental medicine 217. PMID: 32130408
7. Karlowitz, R. et al. (2022) Cell death & disease 13, 684. PMID: 35933402
8. Huang, X. et al. (2019) Cancer immunology research 7, 1580-1590. PMID: 31399419
9. Roedig, J. et al. (2021) EMBO reports 22, e50163. PMID: 33369872 - Note: For research use only.
Images
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Western blotWestern blot analysis was performed using anti-USP22 polyclonal antibody at 1µg/ml on various samples.
Lane 1: HepG2 cell lysate
Datasheet
