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Anti-SP1 Polyclonal Antibody

Anti-SP1 Polyclonal Antibody

  • Catalog number: PA12849
  • Availability: In Stock

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  • $168.00

  • Ex Tax: $168.00

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  • Host species: Rabbit
  • Species reactivity: Human, Mouse, Rat
  • Immunogen: E. coli - derived recombinant Human SP1 (Leu260-Ala591).
  • Form: Liquid
  • Storage buffer: 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
  • Clonality: Polyclonal
  • Isotype: IgG
  • Applications: ELISA, IHC, WB
  • Target: SP1, TSFP1, Transcription factor Sp1
  • Purification: Purified by antigen affinity column.
  • Stability and Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
  • Background: Transcription factor Sp1 is a ~80 kDa protein. Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Also binds the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage.
    References:
    1. Ding, H. et al. (1999) The Journal of biological chemistry 274, 19573-80. PMID: 10391891
    2. Yang, X. et al. (2001) Proceedings of the National Academy of Sciences of the United States of America 98, 6611-6. PMID: 11371615
    3. Milanini-Mongiat, J. et al. (2002) The Journal of biological chemistry 277, 20631-9. PMID: 11904305
    4. Bonello, MR. et al. (2004) The Journal of biological chemistry 279, 2377-82. PMID: 14593115
    5. Hsu, MC. et al. (2006) The Journal of biological chemistry 281, 4718-25. PMID: 16377629
    6. Hung, JJ. et al. (2006) Molecular and cellular biology 26, 1770-85. PMID: 16478997
    7. Zhang, Y. et al. (2006) Molecular and cellular biology 26, 6748-61. PMID: 16943418
    8. Vicart, A. et al. (2006) Journal of molecular biology 364, 897-908. PMID: 17049555
    9. Olofsson, BA. et al. (2007) Molecular cancer research : MCR 5, 1319-30. PMID: 18171990
    10. Chuang, JY. et al. (2008) Molecular biology of the cell 19, 1139-51. PMID: 18199680
  • Note: For research use only.

Images

  • Western blot for Anti-SP1 Polyclonal Antibody
    Western blot

    Western blot analysis was performed using anti-SP1 polyclonal antibody at 1μg/ml on various samples.
    Lane 1: Jurkat cell lysate
    Lane 2: K562 cell lysate
    Lane 3: HepG2 cell lysate

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