Anti-KYAT1 Polyclonal Antibody
- Catalog number: PA12852
- Availability: In Stock
$168.00
- Ex Tax: $168.00
- Host species: Rabbit
- Species reactivity: Human, Mouse, Rat
- Immunogen: E. coli - derived recombinant Human KYAT1 (Met1-Leu372).
- Form: Liquid
- Storage buffer: 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
- Clonality: Polyclonal
- Isotype: IgG
- Applications: ELISA, IHC, WB
- Target: KATI, Cysteine-S-conjugate beta-lyase, Glutamine--phenylpyruvate transaminase, Kynurenine--oxoglutarate transaminase 1, Kynurenine--oxoglutarate transaminase I, KYAT1, Kynurenine aminotransferase 1, CCBL1, GTK, Glutamine transaminase K, Kynurenine aminotransferase I
- Purification: Purified by antigen affinity column.
- Stability and Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
- Background: Kynurenine--oxoglutarate transaminase 1 (KYAT1) is a ~47 kDa protein. Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA), an intermediate in the tryptophan catabolic pathway which is also a broad spectrum antagonist of the three ionotropic excitatory amino acid receptors among others. Also metabolizes the cysteine conjugates of certain halogenated alkenes and alkanes to form reactive metabolites. Catalyzes the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond.
References:
1. Han, Q. et al. (2009) Journal of medicinal chemistry 52, 2786-93. PMID: 19338303
2. Nadvi, NA. et al. (2017) Protein science : a publication of the Protein Society 26, 727-736. PMID: 28097769
3. Perry, S. et al. (1995) FEBS letters 360, 277-80. PMID: 7883047 - Note: For research use only.
Images
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Western blotWestern blot analysis was performed using anti-KYAT1 polyclonal antibody at 1μg/ml on various samples.
Lane 1: Raji cell lysate
Lane 2: SW620 cell lysate
Lane 3: Mouse liver lysate
Lane 4: Mouse kidney lysate
Lane 5: Mouse heart lysate
Datasheet
