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Anti-ALDH7A1 Polyclonal Antibody

Anti-ALDH7A1 Polyclonal Antibody

  • Catalog number: PA12954
  • Availability: In Stock

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  • $168.00

  • Ex Tax: $168.00

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  • Host species: Rabbit
  • Species reactivity: Human, Mouse, Rat
  • Immunogen: E. coli - derived recombinant Human ALDH7A1 (Met1-Gln539).
  • Form: Liquid
  • Storage buffer: 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
  • Clonality: Polyclonal
  • Isotype: IgG
  • Applications: ELISA, IHC, WB
  • Target: ALDH7A1, Delta1-piperideine-6-carboxylate dehydrogenase, Antiquitin-1, P6c dehydrogenase, Alpha-AASA dehydrogenase, Alpha-aminoadipic semialdehyde dehydrogenase, Aldehyde dehydrogenase family 7 member A1, Betaine aldehyde dehydrogenase, ATQ1
  • Purification: Purified by antigen affinity column.
  • Stability and Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
  • Background: Alpha-aminoadipic semialdehyde dehydrogenase (ALDH7A1) is a ~58 kDa protein. Aldehyde dehydrogenase enzyme that mediates important protective effects. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in cellular defense against hyperosmotic stress by metabolizing betaine aldehyde to betaine, an important cellular osmolyte and methyl donor.
    References:
    1. Mills, PB. et al. (2006) Nature medicine 12, 307-9. PMID: 16491085
    2. Brocker, C. et al. (2010) The Journal of biological chemistry 285, 18452-63. PMID: 20207735
    3. Mills, PB. et al. (2010) Brain : a journal of neurology 133, 2148-59. PMID: 20554659
    4. Brocker, C. et al. (2011) Chemico-biological interactions 191, 269-77. PMID: 21338592
    5. Luo, M. et al. (2015) ACS chemical biology 10, 693-7. PMID: 25554827
    6. Laciak, AR. et al. (2020) The FEBS journal 287, 173-189. PMID: 31302938
    7. Laciak, AR. et al. (2020) Journal of inherited metabolic disease 43, 635-644. PMID: 31652343
    8. Korasick, DA. et al. (2024) Chemico-biological interactions 394, 110993. PMID: 38604394
    9. Yang, JS. et al. (2025) Cell 188, 2569-2585.e20. PMID: 40233740
  • Note: For research use only.

Images

  • Western blot for Anti-ALDH7A1 Polyclonal Antibody
    Western blot

    Western blot analysis was performed using anti-ALDH7A1 polyclonal antibody at 1µg/ml on various samples.
    Lane 1: 293T cell lysate
    Lane 2: Mouse liver lysate
    Lane 3: Rat liver lysate
    Lane 4: Rat kidney lysate

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