Anti-Human GNPDA1 Polyclonal Antibody
- Catalog number: PA14012
- Availability: In Stock
$168.00
- Ex Tax: $168.00
- Description: Anti-Human GNPDA1 Polyclonal Antibody (PA14012) is a rabbit polyclonal antibody detecting GNPDA1 in ELISA, IHC, WB. Suitable for Human.
Highlights:
• Affinity Purified — Minimal background and high purity for reliable results.
• Multi-Application — Validated across multiple applications. - Host species: Rabbit
- Species reactivity: Human
- Immunogen: E. coli - derived recombinant Human GNPDA1 (Met1-Asp289).
- Form: Liquid
- Storage buffer: 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
- Clonality: Polyclonal
- Isotype: IgG
- Applications: ELISA, IHC, WB
- Target: GNPDA1, GlcN6P deaminase 1, Glucosamine-6-phosphate deaminase 1, GNPI, GNPDA 1, Oscillin, KIAA0060, HLN, Glucosamine-6-phosphate isomerase 1
- Purification: Purified by antigen affinity column.
- Stability and Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
- Background: Glucosamine-6-phosphate deaminase 1 (GNPDA1) is a ~32 kDa protein. Catalyzes the reversible conversion of alpha-D-glucosamine 6-phosphate (GlcN-6P) into beta-D-fructose 6-phosphate (Fru-6P) and ammonium ion, a regulatory reaction step in de novo uridine diphosphate-N-acetyl-alpha-D-glucosamine (UDP-GlcNAc) biosynthesis via hexosamine pathway. Deamination is coupled to aldo-keto isomerization mediating the metabolic flux from UDP-GlcNAc toward Fru-6P. At high ammonium level can drive amination and isomerization of Fru-6P toward hexosamines and UDP-GlcNAc synthesis. Has a role in fine tuning the metabolic fluctuations of cytosolic UDP-GlcNAc and their effects on hyaluronan synthesis that occur during tissue remodeling. Seems to trigger calcium oscillations in mammalian eggs.
References:
1. Alvarez-Añorve, LI. et al. (2011) Biochimica et biophysica acta 1814, 1846-53. PMID: 21807125
2. Oikari, S. et al. (2016) Glycobiology 26, 710-22. PMID: 26887390 - Note: For research use only.
Images
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Western blotWestern blot analysis was performed using anti-GNPDA1 polyclonal antibody at 1ug/mL on various samples.
Lane 1: U87 cell lysate
