Anti-TROP2 & Anti-HSG Bispecific Reference Antibody (TF12)
- Catalog number: BS11485
- Availability: In Stock
$742.00
- Ex Tax: $742.00
Description: Mitumomab (YP464026) is a research-grade recombinant antibody targeting Ganglioside GD3. Produced in mammalian cells with native-like glycosylation.
Highlights:
• Research Grade — For PK/PD studies, assay development, and ADA research.
• Native Glycosylation — Mammalian expression ensures native-like patterns.
Host species: Humanized
Isotype: (Fab)2-Fab'
Species reactivity: Human
Immunogen:
Form: Liquid
Storage instructions:
Storage buffer: 0.01M PBS, pH7.4.
Concentration: 1mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: Research Grade Biosimilar
Target: PancreaticcarcinomamarkerproteinGA733-1,Tumor-associatedcalciumsignaltransducer2,M1S1,TROP2,TACSTD2,CellsurfaceglycoproteinTrop-2,GA733-1,Membranecomponentchromosome1surfacemarker1
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: <1EU/mg, determined by LAL gel clotting assay
Expression system: Mammalian Cells
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names:
Background: Mitumomab is an anti-idiotypic mouse IgG2b monoclonal antibody that mimics the ganglioside GD3. Mitumomab can be used for the research of small-cell lung carcinoma.
References:
1. GD3 ganglioside and apoptosis., PMID:12531552
2. Ganglioside GD3: structure, cellular distribution, and possible function., PMID:3903474
3. Ganglioside GD3 as a raft component in cell death regulation., PMID:21554197
4. A reappraisal of ganglioside GD3 expression in the CNS., PMID:8721669
5. Ganglioside GD3 regulates neural stem cell quiescence and controls postnatal neurogenesis., PMID:37667994
6. Ganglioside GD3 is up-regulated in microglia and regulates phagocytosis following global cerebral ischemia., PMID:34133773
7. Ganglioside GD3 regulates dendritic growth in newborn neurons in adult mouse hippocampus via modulation of mitochondrial dynamics., PMID:32743804
8. Possible regulation of ganglioside GD3 synthase gene expression with DNA methylation in human glioma cells., PMID:36897478
9. Ganglioside GD3 Regulates Inflammation and Epithelial-to-Mesenchymal Transition in Human Nasal Epithelial Cells., PMID:38612859
10. Development of Fluorescent Ganglioside GD3 and GQ1b Analogs for Elucidation of Raft-Associated Interactions., PMID:32951428
Note: For research use only. Not suitable for clinical or therapeutic use.
Highlights:
• Research Grade — For PK/PD studies, assay development, and ADA research.
• Native Glycosylation — Mammalian expression ensures native-like patterns.
Host species: Humanized
Isotype: (Fab)2-Fab'
Species reactivity: Human
Immunogen:
Form: Liquid
Storage instructions:
Storage buffer: 0.01M PBS, pH7.4.
Concentration: 1mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: Research Grade Biosimilar
Target: PancreaticcarcinomamarkerproteinGA733-1,Tumor-associatedcalciumsignaltransducer2,M1S1,TROP2,TACSTD2,CellsurfaceglycoproteinTrop-2,GA733-1,Membranecomponentchromosome1surfacemarker1
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: <1EU/mg, determined by LAL gel clotting assay
Expression system: Mammalian Cells
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names:
Background: Mitumomab is an anti-idiotypic mouse IgG2b monoclonal antibody that mimics the ganglioside GD3. Mitumomab can be used for the research of small-cell lung carcinoma.
References:
1. GD3 ganglioside and apoptosis., PMID:12531552
2. Ganglioside GD3: structure, cellular distribution, and possible function., PMID:3903474
3. Ganglioside GD3 as a raft component in cell death regulation., PMID:21554197
4. A reappraisal of ganglioside GD3 expression in the CNS., PMID:8721669
5. Ganglioside GD3 regulates neural stem cell quiescence and controls postnatal neurogenesis., PMID:37667994
6. Ganglioside GD3 is up-regulated in microglia and regulates phagocytosis following global cerebral ischemia., PMID:34133773
7. Ganglioside GD3 regulates dendritic growth in newborn neurons in adult mouse hippocampus via modulation of mitochondrial dynamics., PMID:32743804
8. Possible regulation of ganglioside GD3 synthase gene expression with DNA methylation in human glioma cells., PMID:36897478
9. Ganglioside GD3 Regulates Inflammation and Epithelial-to-Mesenchymal Transition in Human Nasal Epithelial Cells., PMID:38612859
10. Development of Fluorescent Ganglioside GD3 and GQ1b Analogs for Elucidation of Raft-Associated Interactions., PMID:32951428
Note: For research use only. Not suitable for clinical or therapeutic use.
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