Anti-Mouse CD141/THBD Polyclonal Antibody
- Catalog number: PA14158
- Availability: In Stock
$168.00
- Ex Tax: $168.00
- Description: Anti-Mouse CD141/THBD Polyclonal Antibody (PA14158) is a rabbit polyclonal antibody detecting CD141 in ELISA, IHC, WB. Suitable for Mouse.
Highlights:
• Affinity Purified — Minimal background and high purity for reliable results.
• Multi-Application — Validated across multiple applications. - Host species: Rabbit
- Species reactivity: Mouse
- Immunogen: E. coli - derived recombinant Mouse CD141/THBD (Gln24-Thr170).
- Form: Liquid
- Storage buffer: 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
- Clonality: Polyclonal
- Isotype: IgG
- Applications: ELISA, IHC, WB
- Target: THBD, THRM, CD141, Thrombomodulin, Fetomodulin, TM
- Purification: Purified by antigen affinity column.
- Stability and Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
- Background: Thrombomodulin (CD141/THBD) is a ~61 kDa protein. Endothelial cell receptor that plays a critical role in regulating several physiological processes including hemostasis, coagulation, fibrinolysis, inflammation, and angiogenesis. Acts as a cofactor for thrombin activation of protein C/PROC on the surface of vascular endothelial cells leading to initiation of the activated protein C anticoagulant pathway. Also accelerates the activation of the plasma carboxypeptidase B2/CPB2, which catalyzes removal of C-terminal basic amino acids from its substrates including kinins or anaphylatoxins leading to fibrinolysis inhibition. Plays critical protective roles in changing the cleavage specificity of protease-activated receptor 1/PAR1, inhibiting endothelial cell permeability and inflammation. Suppresses inflammation distinctly from its anticoagulant cofactor activity by sequestering HMGB1 thereby preventing it from engaging cellular receptors such as RAGE and contributing to the inflammatory response.
References:
1. Biswas, I. et al. (2024) Arteriosclerosis, thrombosis, and vascular biology 44, 603-616. PMID: 38174561 - Note: For research use only.
Images
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Western blotWestern blot analysis was performed using anti-THBD polyclonal antibody at 1ug/mL on various samples.
Lane 1: Rat lung lysate
