Anti-Human IGFBP1 Polyclonal Antibody
- Catalog number: PA14338
- Availability: In Stock
$168.00
- Ex Tax: $168.00
- Description: Anti-Human IGFBP1 Polyclonal Antibody (PA14338) is a rabbit polyclonal antibody detecting IGFBP1 in ELISA, IHC, WB. Suitable for Human.
Highlights:
• Affinity Purified — Minimal background and high purity for reliable results.
• Multi-Application — Validated across multiple applications. - Host species: Rabbit
- Species reactivity: Human
- Immunogen: E. coli - derived recombinant Human IGFBP1 (Ala26-Asn259).
- Form: Liquid
- Storage buffer: 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
- Clonality: Polyclonal
- Isotype: IgG
- Applications: ELISA, IHC, WB
- Target: IGFBP-1, IGFBP1, Insulin-like growth factor-binding protein 1, Placental protein 12, IBP1, IGF-binding protein 1, IBP-1, PP12
- Purification: Purified by antigen affinity column.
- Stability and Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
- Background: Insulin-like growth factor-binding protein 1 (IGFBP1) is a ~27 kDa protein. Multifunctional protein that plays a critical role in regulating the availability of IGFs such as IGF1 and IGF2 to their receptors and thereby regulates IGF-mediated cellular processes including cell migration, proliferation, differentiation or apoptosis in a cell-type specific manner. Also plays a positive role in cell migration by interacting with integrin ITGA5:ITGB1 through its RGD motif. Mechanistically, binding to integrins leads to activation of focal adhesion kinase/PTK2 and stimulation of the mitogen-activated protein kinase (MAPK) pathway. Regulates cardiomyocyte apoptosis by suppressing HIF-1alpha/HIF1A ubiquitination and subsequent degradation.
References:
1. Gleeson, LM. et al. (2001) The Journal of clinical endocrinology and metabolism 86, 2484-93. PMID: 11397844
2. Sala, A. et al. (2005) The Journal of biological chemistry 280, 29812-9. PMID: 15972819
3. Jones, JI. et al. (1993) Proceedings of the National Academy of Sciences of the United States of America 90, 10553-7. PMID: 7504269 - Note: For research use only.
Images
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Western blotWestern blot analysis was performed using anti-IGFBP1 polyclonal antibody at 1ug/mL on various samples.
Lane 1: HepG2 cell lysate
