Anti-Human GHR Reference Antibody (DR10112)

Description: Anti-Human GHR (DR10112) (BS11526) is a research-grade recombinant antibody targeting GHR. Produced in mammalian cells with native-like glycosylation.
Highlights:
• Research Grade — For PK/PD studies, assay development, and ADA research.
• Native Glycosylation — Mammalian expression ensures native-like patterns.
Host species: Human
Isotype: IgG
Species reactivity: Human
Immunogen:
Form: Liquid
Storage instructions:
Storage buffer: 0.01M PBS, pH7.4.
Concentration: 1mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: Research Grade Biosimilar
Target: GHR,GH-bindingprotein,Growthhormonereceptor,GHBP,Somatotropinreceptor,GHreceptor,Serum-bindingprotein
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: <1EU/mg, determined by LAL gel clotting assay
Expression system: Mammalian Cells
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names: DR10112
Background: Growth hormone receptor (GHR) is a ~71 kDa protein. Receptor for pituitary gland growth hormone (GH1) involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway.
References:
1. de Vos, AM. et al. (1992) Science (New York, N.Y.) 255, 306-12. PMID: 1549776
2. Leung, DW. et al. (1987) Nature 330, 537-43. PMID: 282503
3. Sundström, M. et al. (1996) The Journal of biological chemistry 271, 32197-203. PMID: 8943276
4. Greenhalgh, CJ. et al. (2005) The Journal of clinical investigation 115, 397-406. PMID: 15690087
Note: For research use only. Not suitable for clinical or therapeutic use.