Anti-Human GP88/GRN Reference Antibody (AG1)
- Catalog number: BS11538
- Availability: In Stock
$370.00
- Ex Tax: $370.00
Description: Anti-Human GP88/GRN (AG1) (BS11538) is a research-grade recombinant antibody targeting PC cell-derived growth factor. Produced in mammalian cells with native-like glycosylation.
Highlights:
• Research Grade — For PK/PD studies, assay development, and ADA research.
• Native Glycosylation — Mammalian expression ensures native-like patterns.
Host species: Human
Isotype: IgG
Species reactivity: Human
Immunogen:
Form: Liquid
Storage instructions:
Storage buffer: 0.01M PBS, pH7.4.
Concentration: 1mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: Research Grade Biosimilar
Target: PCcell-derivedgrowthfactor,GranulinG,Epithelinprecursor,Epithelin-1,GranulinA,Acrogranin,Progranulin,GranulinF,Proepithelin,PGRN,Glycoproteinof88Kda,GRN,GranulinC,GranulinE,Granulinprecursor,PEPI,PCDGF,GranulinD,Glycoprotein88,Epithelin-2,GP88,GranulinB
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: <1EU/mg, determined by LAL gel clotting assay
Expression system: Mammalian Cells
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names: AG1
Background: Progranulin (GP88/GRN) is a ~63 kDa protein. Secreted protein that acts as a key regulator of lysosomal function and as a growth factor involved in inflammation, wound healing and cell proliferation. Regulates protein trafficking to lysosomes, and also the activity of lysosomal enzymes. Also facilitates the acidification of lysosomes, causing degradation of mature CTSD by CTSB. In addition, functions as a wound-related growth factor that acts directly on dermal fibroblasts and endothelial cells to promote division, migration and the formation of capillary-like tubule structures. Also promotes epithelial cell proliferation by blocking TNF-mediated neutrophil activation preventing release of oxidants and proteases.
References:
1. Zhu, J. et al. (2002) Cell 111, 867-78. PMID: 12526812
2. Van Damme, P. et al. (2008) The Journal of cell biology 181, 37-41. PMID: 18378771
3. Tanaka, Y. et al. (2017) Human molecular genetics 26, 969-988. PMID: 28073925
4. Beel, S. et al. (2017) Human molecular genetics 26, 2850-2863. PMID: 28453791
5. Zhou, X. et al. (2017) Nature communications 8, 15277. PMID: 28541286
Note: For research use only. Not suitable for clinical or therapeutic use.
Highlights:
• Research Grade — For PK/PD studies, assay development, and ADA research.
• Native Glycosylation — Mammalian expression ensures native-like patterns.
Host species: Human
Isotype: IgG
Species reactivity: Human
Immunogen:
Form: Liquid
Storage instructions:
Storage buffer: 0.01M PBS, pH7.4.
Concentration: 1mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: Research Grade Biosimilar
Target: PCcell-derivedgrowthfactor,GranulinG,Epithelinprecursor,Epithelin-1,GranulinA,Acrogranin,Progranulin,GranulinF,Proepithelin,PGRN,Glycoproteinof88Kda,GRN,GranulinC,GranulinE,Granulinprecursor,PEPI,PCDGF,GranulinD,Glycoprotein88,Epithelin-2,GP88,GranulinB
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: <1EU/mg, determined by LAL gel clotting assay
Expression system: Mammalian Cells
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names: AG1
Background: Progranulin (GP88/GRN) is a ~63 kDa protein. Secreted protein that acts as a key regulator of lysosomal function and as a growth factor involved in inflammation, wound healing and cell proliferation. Regulates protein trafficking to lysosomes, and also the activity of lysosomal enzymes. Also facilitates the acidification of lysosomes, causing degradation of mature CTSD by CTSB. In addition, functions as a wound-related growth factor that acts directly on dermal fibroblasts and endothelial cells to promote division, migration and the formation of capillary-like tubule structures. Also promotes epithelial cell proliferation by blocking TNF-mediated neutrophil activation preventing release of oxidants and proteases.
References:
1. Zhu, J. et al. (2002) Cell 111, 867-78. PMID: 12526812
2. Van Damme, P. et al. (2008) The Journal of cell biology 181, 37-41. PMID: 18378771
3. Tanaka, Y. et al. (2017) Human molecular genetics 26, 969-988. PMID: 28073925
4. Beel, S. et al. (2017) Human molecular genetics 26, 2850-2863. PMID: 28453791
5. Zhou, X. et al. (2017) Nature communications 8, 15277. PMID: 28541286
Note: For research use only. Not suitable for clinical or therapeutic use.
Images
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SDS-PAGESDS-PAGE for Research Grade Anti-Human CD340/ERBB2/HER2/NEU (SYD983)
