Anti-Human SLC25A12 Polyclonal Antibody
- Catalog number: PA14675
- Availability: In Stock
$168.00
- Ex Tax: $168.00
- Description: Anti-Human SLC25A12 Polyclonal Antibody (PA14675) is a rabbit polyclonal antibody detecting SLC25A12 in ELISA, IHC, WB. Suitable for Human.
Highlights:
• Affinity Purified — Minimal background and high purity for reliable results.
• Multi-Application — Validated across multiple applications. - Host species: Rabbit
- Species reactivity: Human
- Immunogen: E. coli - derived recombinant Human SLC25A12 (Gly11-Gln311).
- Form: Liquid
- Storage buffer: 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
- Clonality: Polyclonal
- Isotype: IgG
- Applications: ELISA, IHC, WB
- Target: Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial, Araceli hiperlarga, Aralar, Aralar1, Mitochondrial aspartate glutamate carrier 1, Solute carrier family 25 member 12, SLC25A12, AGC1, ARALAR1
- Purification: Purified by antigen affinity column.
- Stability and Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
- Background: Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial is a ~74 kDa protein. Mitochondrial electrogenic aspartate/glutamate antiporter that favors efflux of aspartate and entry of glutamate and proton within the mitochondria as part of the malate-aspartate shuttle. Also mediates the uptake of L-cysteinesulfinate (3-sulfino-L-alanine) by mitochondria in exchange of L-glutamate and proton. Can also exchange L-cysteinesulfinate with aspartate in their anionic form without any proton translocation. Lacks transport activity towards L-glutamine or gamma-aminobutyric acid (GABA).
References:
1. Palmieri, L. et al. (2001) The EMBO journal 20, 5060-9. PMID: 11566871
2. Wibom, R. et al. (2009) The New England journal of medicine 361, 489-95. PMID: 19641205
3. Falk, MJ. et al. (2014) JIMD reports 14, 77-85. PMID: 24515575
4. Porcelli, V. et al. (2024) Biochimica et biophysica acta. Bioenergetics 1865, 149487. PMID: 38945283 - Note: For research use only.
Images
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Western blotWestern blot analysis was performed using anti-SLC25A12 polyclonal antibody at SLC25A12 on various samples.
Lane 1: Jurkat cell lysate
Lane 2: A431 cell lysate
Lane 3: Mouse brain lysate
Lane 4: Mouse skeletal muscle lysate
Lane 5: Rat brain lysate
Lane 6: Rat skeletal muscle lysate
