Anti-HCV NS1/Envelope glycoprotein E2 Reference Antibody (MBL-HCV1)
- Catalog number: BS11545
- Availability: In Stock
$370.00
- Ex Tax: $370.00
Description: Anti-HCV NS1/Envelope glycoprotein E2 (MBL-HCV1) (BS11545) is a research-grade recombinant antibody targeting NS1. Produced in mammalian cells with native-like glycosylation.
Highlights:
• Research Grade — For PK/PD studies, assay development, and ADA research.
• Native Glycosylation — Mammalian expression ensures native-like patterns.
Host species: Human
Isotype: IgG1-kappa
Species reactivity: HepatitisCVirus(HCV)
Immunogen:
Form: Liquid
Storage instructions:
Storage buffer: 0.01M PBS, pH7.4.
Concentration: 1mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: Research Grade Biosimilar
Target: NS1,gp68,gp70,EnvelopeglycoproteinE2,Genomepolyprotein
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: <1EU/mg, determined by LAL gel clotting assay
Expression system: Mammalian Cells
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names: MBL-HCV1,MBLHCV1
Background: Genome polyprotein (NS1/gp68) is a ~327 kDa protein. Packages viral RNA to form a viral nucleocapsid, and promotes virion budding (Probable). Participates in the viral particle production as a result of its interaction with the non-structural protein 5A. Binds RNA and may function as a RNA chaperone to induce the RNA structural rearrangements taking place during virus replication. Modulates viral translation initiation by interacting with viral IRES and 40S ribosomal subunit. Affects various cell signaling pathways, host immunity and lipid metabolism (Probable).
References:
1. Ivanyi-Nagy, R. et al. (2008) Nucleic acids research 36, 712-25. PMID: 18033802
2. Anjum, S. et al. (2013) Molecular medicine reports 8, 487-92. PMID: 23799612
3. Kittlesen, DJ. et al. (2000) The Journal of clinical investigation 106, 1239-49. PMID: 11086025
4. Waggoner, SN. et al. (2007) Journal of leukocyte biology 82, 1407-19. PMID: 17881511
5. Ruggieri, A. et al. (2003) Virus research 97, 103-10. PMID: 14602201
Note: For research use only. Not suitable for clinical or therapeutic use.
Highlights:
• Research Grade — For PK/PD studies, assay development, and ADA research.
• Native Glycosylation — Mammalian expression ensures native-like patterns.
Host species: Human
Isotype: IgG1-kappa
Species reactivity: HepatitisCVirus(HCV)
Immunogen:
Form: Liquid
Storage instructions:
Storage buffer: 0.01M PBS, pH7.4.
Concentration: 1mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: Research Grade Biosimilar
Target: NS1,gp68,gp70,EnvelopeglycoproteinE2,Genomepolyprotein
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: <1EU/mg, determined by LAL gel clotting assay
Expression system: Mammalian Cells
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names: MBL-HCV1,MBLHCV1
Background: Genome polyprotein (NS1/gp68) is a ~327 kDa protein. Packages viral RNA to form a viral nucleocapsid, and promotes virion budding (Probable). Participates in the viral particle production as a result of its interaction with the non-structural protein 5A. Binds RNA and may function as a RNA chaperone to induce the RNA structural rearrangements taking place during virus replication. Modulates viral translation initiation by interacting with viral IRES and 40S ribosomal subunit. Affects various cell signaling pathways, host immunity and lipid metabolism (Probable).
References:
1. Ivanyi-Nagy, R. et al. (2008) Nucleic acids research 36, 712-25. PMID: 18033802
2. Anjum, S. et al. (2013) Molecular medicine reports 8, 487-92. PMID: 23799612
3. Kittlesen, DJ. et al. (2000) The Journal of clinical investigation 106, 1239-49. PMID: 11086025
4. Waggoner, SN. et al. (2007) Journal of leukocyte biology 82, 1407-19. PMID: 17881511
5. Ruggieri, A. et al. (2003) Virus research 97, 103-10. PMID: 14602201
Note: For research use only. Not suitable for clinical or therapeutic use.
Images
-
Western blotWestern blot analysis was performed using anti-glycoprotein E2 monoclonal antibody at 1ug/mL on various samples.
Lane 1: recombinant hepatitis C virus (Catalog No: PV11073)
Lane 2: negative control -
BioactivityDetects recombinant HCV NS1/gp68/gp70/Envelope glycoprotein E2 (Catalog No: PV11073) in indirect ELISA
