Anti-Human ETHE1 Polyclonal Antibody
- Catalog number: PA14718
- Availability: In Stock
$168.00
- Ex Tax: $168.00
- Description: Anti-Human ETHE1 Polyclonal Antibody (PA14718) is a rabbit polyclonal antibody detecting ETHE1 in ELISA, IHC, WB. Suitable for Human.
Highlights:
• Affinity Purified — Minimal background and high purity for reliable results.
• Multi-Application — Validated across multiple applications. - Host species: Rabbit
- Species reactivity: Human
- Immunogen: E. coli - derived recombinant Human ETHE1 (Ile23-Ala254).
- Form: Liquid
- Storage buffer: 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
- Clonality: Polyclonal
- Isotype: IgG
- Applications: ELISA, IHC, WB
- Target: Persulfide dioxygenase ETHE1, mitochondrial, 1.13.11.18, Ethylmalonic encephalopathy protein 1, Hepatoma subtracted clone one protein, Sulfur dioxygenase ETHE1, ETHE1, HSCO
- Purification: Purified by antigen affinity column.
- Stability and Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
- Background: Persulfide dioxygenase ETHE1, mitochondrial is a ~27 kDa protein. Sulfur dioxygenase that plays an essential role in hydrogen sulfide catabolism in the mitochondrial matrix. Hydrogen sulfide (H(2)S) is first oxidized by SQRDL, giving rise to cysteine persulfide residues. ETHE1 consumes molecular oxygen to catalyze the oxidation of the persulfide, once it has been transferred to a thiophilic acceptor, such as glutathione (R-SSH). Plays an important role in metabolic homeostasis in mitochondria by metabolizing hydrogen sulfide and preventing the accumulation of supraphysiological H(2)S levels that have toxic effects, due to the inhibition of cytochrome c oxidase. First described as a protein that can shuttle between the nucleus and the cytoplasm and suppress p53-induced apoptosis by sequestering the transcription factor RELA/NFKB3 in the cytoplasm and preventing its accumulation in the nucleus.
References:
1. Higashitsuji, H. et al. (2002) Cancer cell 2, 335-46. PMID: 12398897 - Note: For research use only.
Images
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Western blotWestern blot analysis was performed using anti-ETHE1 polyclonal antibody at ETHE1 on various samples.
Lane 1: Mouse kidney lysate
Lane 2: Mouse colon lysate
Lane 3: Rat liver lysate
Lane 4: Rat kidney lysate
Datasheet
