Anti-Human ESRRB Polyclonal Antibody
- Catalog number: PA14723
- Availability: In Stock
$168.00
- Ex Tax: $168.00
- Description: Anti-Human ESRRB Polyclonal Antibody (PA14723) is a rabbit polyclonal antibody detecting ESRRB in ELISA, IHC, WB. Suitable for Human.
Highlights:
• Affinity Purified — Minimal background and high purity for reliable results.
• Multi-Application — Validated across multiple applications. - Host species: Rabbit
- Species reactivity: Human
- Immunogen: E. coli - derived recombinant Human ESRRB (Gly235-Val433).
- Form: Liquid
- Storage buffer: 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
- Clonality: Polyclonal
- Isotype: IgG
- Applications: ELISA, IHC, WB
- Target: ERR-beta, NR3B2, Estrogen-related receptor beta, ESRL2, Estrogen receptor-like 2, ERR beta-2, ESRRB, Nuclear receptor subfamily 3 group B member 2, Steroid hormone receptor ERR2, ERRB2
- Purification: Purified by antigen affinity column.
- Stability and Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
- Background: Steroid hormone receptor ERR2 (ESRRB) is a ~48 kDa protein. Transcription factor that binds a canonical ESRRB recognition (ERRE) sequence 5'TCAAGGTCA-3' localized on promoter and enhancer of targets genes regulating their expression or their transcription activity. Plays a role, in a LIF-independent manner, in maintainance of self-renewal and pluripotency of embryonic and trophoblast stem cells through different signaling pathways including FGF signaling pathway and Wnt signaling pathways. Involved in morula development (2-16 cells embryos) by acting as a regulator at the 8-cell stage. Upon FGF signaling pathway activation, interacts with KDM1A by directly binding to enhancer site of ELF5 and EOMES and activating their transcription leading to self-renewal of trophoblast stem cells. Also regulates expression of multiple rod-specific genes and is required for survival of this cell type.
References:
1. Zhou, W. et al. (2007) Molecular and cellular endocrinology 278, 52-62. PMID: 17920186
2. Bombail, V. et al. (2010) Molecular and cellular endocrinology 314, 53-61. PMID: 19755138
3. Cho, Y. et al. (2013) The Journal of biological chemistry 288, 25207-25218. PMID: 23836911 - Note: For research use only.
Images
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Western blotWestern blot analysis was performed using anti-ESRRB polyclonal antibody at 1ug/mL on various samples.
Lane 1: Mouse heart lysate
Lane 2: Rat heart lysate
Datasheet
