Anti-Human HAMP/Hepcidin Reference Antibody (LY2787106)
- Catalog number: BS11548
- Availability: In Stock
$370.00
- Ex Tax: $370.00
Description: Anti-Human HAMP/Hepcidin (LY2787106) (BS11548) is a research-grade recombinant antibody targeting Putative liver tumor regressor. Produced in mammalian cells with native-like glycosylation.
Highlights:
• Research Grade — For PK/PD studies, assay development, and ADA research.
• Native Glycosylation — Mammalian expression ensures native-like patterns.
Host species: Human
Isotype: IgG
Species reactivity: Human
Immunogen:
Form: Liquid
Storage instructions:
Storage buffer: 0.01M PBS, pH7.4.
Concentration: 1mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: Research Grade Biosimilar
Target: Putativelivertumorregressor,HEPC,LEAP-1,Liver-expressedantimicrobialpeptide1,PLTR,Hepcidin,LEAP1,Hepc25,Hepc20,HAMP
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: <1EU/mg, determined by LAL gel clotting assay
Expression system: Mammalian Cells
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names: LY2787106
Background: Hepcidin (HAMP) is a ~9 kDa protein. Liver-produced hormone that constitutes the main circulating regulator of iron absorption and distribution across tissues. Acts by promoting endocytosis and degradation of ferroportin/SLC40A1, leading to the retention of iron in iron-exporting cells and decreased flow of iron into plasma. Controls the major flows of iron into plasma: absorption of dietary iron in the intestine, recycling of iron by macrophages, which phagocytose old erythrocytes and other cells, and mobilization of stored iron from hepatocytes.
References:
1. Qiao, B. et al. (2012) Cell metabolism 15, 918-24. PMID: 22682227
2. Aschemeyer, S. et al. (2018) Blood 131, 899-910. PMID: 29237594
3. Billesbølle, CB. et al. (2020) Nature 586, 807-811. PMID: 32814342
4. Ganz, T. et al. (2012) Biochimica et biophysica acta 1823, 1434-43. PMID: 22306005
Note: For research use only. Not suitable for clinical or therapeutic use.
Highlights:
• Research Grade — For PK/PD studies, assay development, and ADA research.
• Native Glycosylation — Mammalian expression ensures native-like patterns.
Host species: Human
Isotype: IgG
Species reactivity: Human
Immunogen:
Form: Liquid
Storage instructions:
Storage buffer: 0.01M PBS, pH7.4.
Concentration: 1mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: Research Grade Biosimilar
Target: Putativelivertumorregressor,HEPC,LEAP-1,Liver-expressedantimicrobialpeptide1,PLTR,Hepcidin,LEAP1,Hepc25,Hepc20,HAMP
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: <1EU/mg, determined by LAL gel clotting assay
Expression system: Mammalian Cells
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names: LY2787106
Background: Hepcidin (HAMP) is a ~9 kDa protein. Liver-produced hormone that constitutes the main circulating regulator of iron absorption and distribution across tissues. Acts by promoting endocytosis and degradation of ferroportin/SLC40A1, leading to the retention of iron in iron-exporting cells and decreased flow of iron into plasma. Controls the major flows of iron into plasma: absorption of dietary iron in the intestine, recycling of iron by macrophages, which phagocytose old erythrocytes and other cells, and mobilization of stored iron from hepatocytes.
References:
1. Qiao, B. et al. (2012) Cell metabolism 15, 918-24. PMID: 22682227
2. Aschemeyer, S. et al. (2018) Blood 131, 899-910. PMID: 29237594
3. Billesbølle, CB. et al. (2020) Nature 586, 807-811. PMID: 32814342
4. Ganz, T. et al. (2012) Biochimica et biophysica acta 1823, 1434-43. PMID: 22306005
Note: For research use only. Not suitable for clinical or therapeutic use.
Images
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SDS-PAGESDS-PAGE for Research Grade Anti-Human HAMP/Hepcidin (LY2787106)
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BioactivityDetects recombinant Hepcidin (Catalog No: PH16498) in indirect ELISA.
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Western blotWestern blot analysis was performed using anti-Hepcidin monoclonal antibody at 1ug/mL on various samples.
Lane 1: recombinant human Hepcidin (Catalog No: PH16498)
Lane 2: Negative control
