Anti-Human FBXO45 Polyclonal Antibody
- Catalog number: PA14775
- Availability: In Stock
$168.00
- Ex Tax: $168.00
- Description: Anti-Human FBXO45 Polyclonal Antibody (PA14775) is a rabbit polyclonal antibody detecting FBXO45 in ELISA, IHC, WB. Suitable for Human.
Highlights:
• Affinity Purified — Minimal background and high purity for reliable results.
• Multi-Application — Validated across multiple applications. - Host species: Rabbit
- Species reactivity: Human
- Immunogen: E. coli - derived recombinant Human FBXO45 (Ser41-Gly286).
- Form: Liquid
- Storage buffer: 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
- Clonality: Polyclonal
- Isotype: IgG
- Applications: ELISA, IHC, WB
- Target: F-box/SPRY domain-containing protein 1, F-box only protein 45, hFbxo45, FBXO45, FBX45
- Purification: Purified by antigen affinity column.
- Stability and Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
- Background: F-box/SPRY domain-containing protein 1 (FBXO45) is a ~30 kDa protein. Component of E3 ubiquitin ligase complex consisting of FBXO45, MYCBP2 and SKP1. Functions in substrate recognition but also plays an important role in assembly of the complex. Required for normal neuromuscular synaptogenesis, axon pathfinding and neuronal migration. Regulates neuron migration during brain development through interaction with N-cadherin/CDH2 after secretion via a non-classical mechanism. Plays a role in the regulation of neurotransmission at mature neurons.
References:
1. Desbois, M. et al. (2018) The Journal of biological chemistry 293, 13897-13909. PMID: 29997255
2. Richter, KT. et al. (2020) Cell death and differentiation 27, 758-772. PMID: 31285543
3. Tsai, M. et al. (2022) The Journal of biological chemistry 298, 102698. PMID: 36379255 - Note: For research use only.
Images
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Western blotWestern blot analysis was performed using anti-FBXO45 polyclonal antibody at FBXO45 on various samples.
Lane 1: Mouse brain lysate
