Anti-Mouse CD172a/SIRPA Polyclonal Antibody
- Catalog number: PA14975
- Availability: In Stock
$168.00
- Ex Tax: $168.00
- Description: Anti-Mouse CD172a/SIRPA Polyclonal Antibody (PA14975) is a rabbit polyclonal antibody detecting CD172a in ELISA, IHC, WB. Suitable for Mouse.
Highlights:
• Affinity Purified — Minimal background and high purity for reliable results.
• Multi-Application — Validated across multiple applications. - Host species: Rabbit
- Species reactivity: Mouse
- Immunogen: E. coli - derived recombinant Mouse CD172a/SIRPA (Gly31-Gly350).
- Form: Liquid
- Storage buffer: 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
- Clonality: Polyclonal
- Isotype: IgG
- Applications: ELISA, IHC, WB
- Target: Tyrosine-protein phosphatase non-receptor type substrate 1, SHP substrate 1, SHPS-1, Brain Ig-like molecule with tyrosine-based activation motifs, Bit, CD172 antigen-like family member A, Inhibitory receptor SHPS-1, MyD-1 antigen, Signal-regulatory protein alpha-1, Sirp-alpha-1, mSIRP-alpha1, p84, CD172a, Sirpa, Bit, Myd1, Ptpns1, Shps1, Sirp
- Purification: Purified by antigen affinity column.
- Stability and Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
- Background: Tyrosine-protein phosphatase non-receptor type substrate 1 (CD172a/SIRPA) is a ~56 kDa protein. Immunoglobulin-like cell surface receptor for CD47. Acts as a docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function. Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin.
References:
1. Nakaishi, A. et al. (2008) Journal of molecular biology 375, 650-60. PMID: 18045614
2. Sarute, N. et al. (2019) PLoS biology 17, e3000137. PMID: 30726215 - Note: For research use only.
Images
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Western blotWestern blot analysis was performed using anti-SIRPA polyclonal antibody at SIRPA on various samples.
Lane 1: Mouse brain lysate
Lane 2: Mouse cerebellum lysate
Lane 3: Rat brain lysate
