Anti-Human PSME3 Polyclonal Antibody
- Catalog number: PA15418
- Availability: In Stock
$168.00
- Ex Tax: $168.00
- Description: Anti-Human PSME3 Polyclonal Antibody (PA15418) is a rabbit polyclonal antibody detecting PSME3 in ELISA, IHC, WB. Suitable for Human.
Highlights:
• Affinity Purified — Minimal background and high purity for reliable results.
• Multi-Application — Validated across multiple applications. - Host species: Rabbit
- Species reactivity: Human
- Immunogen: E. coli - derived recombinant Human PSME3 (Ser111-Tyr254).
- Form: Liquid
- Storage buffer: 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
- Clonality: Polyclonal
- Isotype: IgG
- Applications: ELISA, IHC, WB
- Target: Activator of multicatalytic protease subunit 3, Proteasome activator complex subunit 3, PA28g, 11S regulator complex subunit gamma, PA28gamma, Ki nuclear autoantigen, REG-gamma, PSME3, Proteasome activator 28 subunit gamma
- Purification: Antigen affinity purification.
- Stability and Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
- Background: Proteasome activator complex subunit 3 (PSME3) is a ~29 kDa protein. Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation. Mediates CCAR2 and CHEK2-dependent SIRT1 inhibition.
References:
1. Magni, M. et al. (2014) Nucleic acids research 42, 13150-60. PMID: 25361978 - Note: For research use only.
Images
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Western blotWestern blot analysis was performed using anti-PSME3 polyclonal antibody at 1ug/mL on various samples.
Lane 1: HepG2 cell lysate
Lane 2: Hela cell lysate
Lane 3: K562 cell lysate
Lane 4: 293T cell lysate
Datasheet
