Anti-Human IL1A/IL1F1 Reference Antibody (XB2001)
- Catalog number: BS11657
- Availability: In Stock
$370.00
- Ex Tax: $370.00
Description: Anti-Human IL1A/IL1F1 (XB2001) (BS11657) is a research-grade recombinant antibody targeting IL1F1. Produced in mammalian cells with native-like glycosylation.
Highlights:
• Research Grade — For PK/PD studies, assay development, and ADA research.
• Native Glycosylation — Mammalian expression ensures native-like patterns.
Host species: Human
Isotype: IgG
Species reactivity: Human
Immunogen:
Form: Liquid
Storage instructions:
Storage buffer: 0.01M PBS, pH7.4.
Concentration: 1mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: Research Grade Biosimilar
Target: IL1F1,Interleukin-1alpha,IL1A,Hematopoietin-1,IL-1alpha
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: <1EU/mg, determined by LAL gel clotting assay
Expression system: Mammalian Cells
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names: XB2001
Background: Interleukin-1 alpha (IL1A/IL1F1) is a ~30 kDa protein. Cytokine constitutively present intracellularly in nearly all resting non-hematopoietic cells that plays an important role in inflammation and bridges the innate and adaptive immune systems. After binding to its receptor IL1R1 together with its accessory protein IL1RAP, forms the high affinity interleukin-1 receptor complex. Signaling involves the recruitment of adapter molecules such as MYD88, IRAK1 or IRAK4. In turn, mediates the activation of NF-kappa-B and the three MAPK pathways p38, p42/p44 and JNK pathways. Within the cell, acts as an alarmin and cell death results in its liberation in the extracellular space after disruption of the cell membrane to induce inflammation and alert the host to injury or damage.
References:
1. Cohen, I. et al. (2015) Scientific reports 5, 14756. PMID: 26439902
2. Brikos, C. et al. (2007) Molecular & cellular proteomics : MCP 6, 1551-9. PMID: 17507369
3. Mosley, B. et al. (1987) The Journal of biological chemistry 262, 2941-4. PMID: 2950091
4. Wu, T. et al. (2004) Cytokine 25, 11-20. PMID: 14687581
5. Spiekstra, SW. et al. (2005) Experimental dermatology 14, 109-16. PMID: 15679580
Note: For research use only. Not suitable for clinical or therapeutic use.
Highlights:
• Research Grade — For PK/PD studies, assay development, and ADA research.
• Native Glycosylation — Mammalian expression ensures native-like patterns.
Host species: Human
Isotype: IgG
Species reactivity: Human
Immunogen:
Form: Liquid
Storage instructions:
Storage buffer: 0.01M PBS, pH7.4.
Concentration: 1mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: Research Grade Biosimilar
Target: IL1F1,Interleukin-1alpha,IL1A,Hematopoietin-1,IL-1alpha
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: <1EU/mg, determined by LAL gel clotting assay
Expression system: Mammalian Cells
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names: XB2001
Background: Interleukin-1 alpha (IL1A/IL1F1) is a ~30 kDa protein. Cytokine constitutively present intracellularly in nearly all resting non-hematopoietic cells that plays an important role in inflammation and bridges the innate and adaptive immune systems. After binding to its receptor IL1R1 together with its accessory protein IL1RAP, forms the high affinity interleukin-1 receptor complex. Signaling involves the recruitment of adapter molecules such as MYD88, IRAK1 or IRAK4. In turn, mediates the activation of NF-kappa-B and the three MAPK pathways p38, p42/p44 and JNK pathways. Within the cell, acts as an alarmin and cell death results in its liberation in the extracellular space after disruption of the cell membrane to induce inflammation and alert the host to injury or damage.
References:
1. Cohen, I. et al. (2015) Scientific reports 5, 14756. PMID: 26439902
2. Brikos, C. et al. (2007) Molecular & cellular proteomics : MCP 6, 1551-9. PMID: 17507369
3. Mosley, B. et al. (1987) The Journal of biological chemistry 262, 2941-4. PMID: 2950091
4. Wu, T. et al. (2004) Cytokine 25, 11-20. PMID: 14687581
5. Spiekstra, SW. et al. (2005) Experimental dermatology 14, 109-16. PMID: 15679580
Note: For research use only. Not suitable for clinical or therapeutic use.
Images
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SDS-PAGESDS-PAGE for Research Grade Anti-Human IL1A/IL1F1 (XB2001)
