Anti-Human FLT1/VEGFR1 Monoclonal Antibody (1A418)

Description: Anti-Human FLT1/VEGFR1 Monoclonal Antibody (1A418) [1A418] (MA10414) is a mouse monoclonal antibody detecting VEGFR1 in ELISA. Suitable for Human.
Host species: Mouse
Conjugation: None
Species reactivity: Human
Isotype: IgG
Immunogen: Human FLT1/VEGFR1 Protein.
Form: Liquid
Storage buffer: 0.01M PBS, pH 7.4.
Clonality: Monoclonal
Applications: ELISA
Target: Vascular endothelial growth factor receptor 1, VEGFR-1, 2.7.10.1, Fms-like tyrosine kinase 1, FLT-1, Tyrosine-protein kinase FRT, Tyrosine-protein kinase receptor FLT, FLT, Vascular permeability factor receptor, FLT1, FLT, FRT, VEGFR1
Purification: Protein A/G purified from cell culture supernatant.
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names: N/A
Background: Vascular endothelial growth factor receptor 1 (FLT1/VEGFR1) is a ~150 kDa protein. Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. Acts as a positive regulator of postnatal retinal hyaloid vessel regression. May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. Can promote endothelial cell proliferation, survival and angiogenesis in adulthood. Its function in promoting cell proliferation seems to be cell-type specific.
References:
1. Lesslie, DP. et al. (2006) British journal of cancer 94, 1710-7. PMID: 16685275
Note: For research use only.