Anti-Human CD133/PROM1 antibody

Description: Anti-Human CD133/PROM1 antibody (RA10003) is a human monoclonal antibody detecting PROM1 in ELISA, WB. Suitable for Human.
Host species: Human
Isotype: IgG1
Species reactivity: Human
Form: Liquid
Storage buffer: 0.01M PBS, pH 7.4.
Concentration: 1 mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: ELISA, WB
Target: PROML1,PROM1,Prominin-1,Antigen AC133,CD133,Prominin-like protein 1
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: Please contact with the lab for this information.
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names:
Background: Prominin-1 (CD133/PROM1) is a ~97 kDa protein. May play a role in cell differentiation, proliferation and apoptosis. Binds cholesterol in cholesterol-containing plasma membrane microdomains and may play a role in the organization of the apical plasma membrane in epithelial cells. During early retinal development acts as a key regulator of disk morphogenesis. Involved in regulation of MAPK and Akt signaling pathways. In neuroblastoma cells suppresses cell differentiation such as neurite outgrowth in a RET-dependent manner.
References:
1. Mak, AB. et al. (2014) Journal of molecular biology 426, 2175-82. PMID: 24556617
2. Takenobu, H. et al. (2011) Oncogene 30, 97-105. PMID: 20818439
Note: For research use only.