Anti-LASV GPC Antibody (25.6A)

Host species: Human
Isotype: IgG1, kappa
Species reactivity: Lassa virus (strain Mouse/Sierra Leone/Josiah/1976) (LASV)
Form: Liquid
Storage buffer: 0.01M PBS, pH 7.4.
Concentration: 1 mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: ELISA, Neutralization
Target: Pre-glycoprotein polyprotein GP complex, Pre-GP-C, GPC, GP-C
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: Please contact with the lab for this information.
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names:
Background: Pre-glycoprotein polyprotein GP complex (GPC) is a ~55 kDa protein. Functions as a cleaved signal peptide that is retained as the third component of the GP complex (GP-C). Helps to stabilize the spike complex in its native conformation. The SSP is required for efficient glycoprotein expression, post-translational maturation cleavage of G1 and G2, glycoprotein transport to the cell surface plasma membrane, formation of infectious virus particles, and acid pH-dependent glycoprotein-mediated cell fusion.
References:
1. Katz, M. et al. (2022) Nature 603, 174-179. PMID: 35173332
2. Eichler, R. et al. (2003) EMBO reports 4, 1084-8. PMID: 14555961
Note: For research use only.