Anti-HeV/NiV F/Fusion glycoprotein F0 Antibody (12B2)

Description: Anti-HeV/NiV F/Fusion glycoprotein F0 Antibody (12B2) [12B2] (RA10135) is a mouse monoclonal antibody detecting Fusion glycoprotein F0 in ELISA, Neutralization.
Host species: Mouse
Isotype: IgG1, kappa
Species reactivity: Hendra virus (isolate Horse/Autralia/Hendra/1994) & Nipah virus
Form: Liquid
Storage buffer: 0.01M PBS, pH 7.4.
Concentration: 1 mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: ELISA, Neutralization
Target: F, Fusion glycoprotein F0, Protein F
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: Please contact with the lab for this information.
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names:
Background: Fusion glycoprotein F0 is a ~59 kDa protein. Class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and plasma cell membrane fusion, the heptad repeat (HR) regions assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and plasma cell membranes. Directs fusion of viral and cellular membranes leading to delivery of the nucleocapsid into the cytoplasm.
Note: For research use only.