Anti-HRSV-A G/Major surface glycoprotein G Antibody (3D3)

Description: Anti-HRSV-A G/Major surface glycoprotein G Antibody (3D3) [3D3] (RA10158) is a human monoclonal antibody detecting Major surface glycoprotein G in ELISA, WB.
Host species: Human
Isotype: IgG1, kappa
Species reactivity: Human respiratory syncytial virus A (strain A2)
Form: Liquid
Storage buffer: 0.01M PBS, pH 7.4.
Concentration: 1.5 mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: ELISA, WB
Target: G, Major surface glycoprotein G, Attachment glycoprotein G, Membrane-bound glycoprotein, mG，RSV
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: Please contact with the lab for this information.
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names:
Background: Major surface glycoprotein G is a ~32 kDa protein. Attaches the virion to the host cell membrane by interacting with heparan sulfate, initiating the infection. Interacts with host CX3CR1, the receptor for the CX3C chemokine fractalkine, to modulate the immune response and facilitate infection. Unlike the other paramyxovirus attachment proteins, lacks both neuraminidase and hemagglutinating activities (Probable).
References:
1. Feldman, SA. et al. (1999) Journal of virology 73, 6610-7. PMID: 10400758
2. Feldman, SA. et al. (2000) Journal of virology 74, 6442-7. PMID: 10864656
3. Levine, S. et al. (1987) The Journal of general virology 68 ( Pt 9), 2521-4. PMID: 3655746
4. Tripp, RA. et al. (2001) Nature immunology 2, 732-8. PMID: 1147741
5. Jeong, KI. et al. (2015) PloS one 10, e0130517. PMID: 26107373
6. Johnson, SM. et al. (2015) PLoS pathogens 11, e1005318. PMID: 26658574
Note: For research use only.