Anti-Mouse MMP3 Antibody (CH01)

Description: Anti-Mouse MMP3 Antibody (CH01) [CH01] (RA10519) is a rat monoclonal antibody detecting MMP3 in ELISA, IF. Suitable for Human, Mouse, and Rat.
Highlights:
• Multi-Species — Cross-reactive for translational research.
Host species: Rat
Isotype: IgG1, kappa
Species reactivity: Human, Mouse, Rat
Form: Liquid
Storage buffer: 0.01M PBS, pH 7.4.
Concentration: 1 mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: ELISA, IF
Target: SL-1, Transin-1, MMP-3, MMP3, Matrix metalloproteinase-3, Stromelysin-1, STMY1
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: Please contact with the lab for this information.
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names:
Background: Stromelysin-1 (MMP3) is a ~53 kDa protein. Metalloproteinase with a rather broad substrate specificity that can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates different molecules including growth factors, plasminogen or other matrix metalloproteinases such as MMP9. Once released into the extracellular matrix (ECM), the inactive pro-enzyme is activated by the plasmin cascade signaling pathway. Also acts intracellularly. For example, in dopaminergic neurons, gets activated by the serine protease HTRA2 upon stress and plays a pivotal role in DA neuronal degeneration by mediating microglial activation and alpha-synuclein/SNCA cleavage.
References:
1. Kim, YS. et al. (2007) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 21, 179-87. PMID: 17116747
2. Feng, T. et al. (2022) Antiviral research 206, 105388. PMID: 35940311
Note: For research use only.