Anti-Human CD85k/LILRB4/ILT3 Reference Antibody (TRX385)

Description: Anti-Human CD85k/LILRB4/ILT3 (TRX385) (BS11738) is a research-grade recombinant antibody targeting CD85. Produced in mammalian cells with native-like glycosylation.
Highlights:
• Research Grade — For PK/PD studies, assay development, and ADA research.
• Native Glycosylation — Mammalian expression ensures native-like patterns.
Host species: Human
Isotype: IgG
Species reactivity: Human
Immunogen:
Form: Liquid
Storage instructions:
Storage buffer: 0.01M PBS, pH7.4.
Concentration: 1mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: Research Grade Biosimilar
Target: CD85antigen-likefamilymemberK,LIR-5,Leukocyteimmunoglobulin-likereceptor5,ILT3,ILT-3,Immunoglobulin-liketranscript3,LILRB4,CD85k,Leukocyteimmunoglobulin-likereceptorsubfamilyBmember4,MonocyteinhibitoryreceptorHM18,LIR5
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: <1EU/mg, determined by LAL gel clotting assay
Expression system: Mammalian Cells
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names: TRX385
Background: Leukocyte immunoglobulin-like receptor subfamily B member 4 (CD85k/LILRB4) is a ~49 kDa protein. Inhibitory receptor involved in the down-regulation of the immune response and the development of immune tolerance. Receptor for FN1. Receptor for apolipoprotein APOE. Receptor for ALCAM/CD166. Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.
References:
1. Chang, CC. et al. (2002) Nature immunology 3, 237-43. PMID: 11875462
2. Su, MT. et al. (2021) International immunology 33, 447-458. PMID: 34089617
3. Deng, M. et al. (2018) Nature 562, 605-609. PMID: 30333625
4. Xu, Z. et al. (2018) Journal of immunology (Baltimore, Md. : 1950) 200, 1207-1219. PMID: 29263213
5. Cella, M. et al. (1997) The Journal of experimental medicine 185, 1743-51. PMID: 9151699
6. Lu, HK. et al. (2009) The Journal of biological chemistry 284, 34839-48. PMID: 19833736
7. Kim-Schulze, S. et al. (2006) Journal of immunology (Baltimore, Md. : 1950) 176, 2790-8. PMID: 16493035
Note: For research use only. Not suitable for clinical or therapeutic use.