Anti-Human MASP2 Reference Antibody (CM338)
- Catalog number: BS11745
- Availability: In Stock
$370.00
- Ex Tax: $370.00
Description: Anti-Human MASP2 (CM338) (BS11745) is a research-grade recombinant antibody targeting Mannan-binding lectin serine protease 2. Produced in mammalian cells with native-like glycosylation.
Highlights:
• Research Grade — For PK/PD studies, assay development, and ADA research.
• Native Glycosylation — Mammalian expression ensures native-like patterns.
Host species: Human
Isotype: IgG
Species reactivity: Human
Immunogen:
Form: Liquid
Storage instructions:
Storage buffer: 0.01M PBS, pH7.4.
Concentration: 1mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: Research Grade Biosimilar
Target: Mannan-bindinglectinserineprotease2,Mannose-bindingprotein-associatedserineprotease2,MASP-2,MBL-associatedserineprotease2,MASP2
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: <1EU/mg, determined by LAL gel clotting assay
Expression system: Mammalian Cells
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names: CM338
Background: Mannan-binding lectin serine protease 2 (MASP2) is a ~75 kDa protein. Precursor of a serum protease that activates the lectin pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. The lectin complement system is activated following association of lectins, such as MBL2, FCN1, FCN2 or FCN3, to carbohydrates on the pathogen surface. MASP2 is cleaved and activated by MASP1 in response to lectin-binding to pathogen carbohydrates. Can activate prothrombin to thrombin.
References:
1. Rossi, V. et al. (2001) The Journal of biological chemistry 276, 40880-7. PMID: 11527969
2. Héja, D. et al. (2012) Proceedings of the National Academy of Sciences of the United States of America 109, 10498-503. PMID: 22691502
3. Degn, SE. et al. (2012) Journal of immunology (Baltimore, Md. : 1950) 189, 3957-69. PMID: 22966085
4. Matsushita, M. et al. (2000) Journal of immunology (Baltimore, Md. : 1950) 165, 2637-42. PMID: 10946292
5. Kidmose, RT. et al. (2012) Proceedings of the National Academy of Sciences of the United States of America 109, 15425-30. PMID: 22949645
6. Thiel, S. et al. (1997) Nature 386, 506-10. PMID: 9087411
7. Valenzuela Leon, PC. et al. (2025) Journal of medicinal chemistry 68, 4663-4671. PMID: 39924859
Note: For research use only. Not suitable for clinical or therapeutic use.
Highlights:
• Research Grade — For PK/PD studies, assay development, and ADA research.
• Native Glycosylation — Mammalian expression ensures native-like patterns.
Host species: Human
Isotype: IgG
Species reactivity: Human
Immunogen:
Form: Liquid
Storage instructions:
Storage buffer: 0.01M PBS, pH7.4.
Concentration: 1mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: Research Grade Biosimilar
Target: Mannan-bindinglectinserineprotease2,Mannose-bindingprotein-associatedserineprotease2,MASP-2,MBL-associatedserineprotease2,MASP2
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: <1EU/mg, determined by LAL gel clotting assay
Expression system: Mammalian Cells
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names: CM338
Background: Mannan-binding lectin serine protease 2 (MASP2) is a ~75 kDa protein. Precursor of a serum protease that activates the lectin pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. The lectin complement system is activated following association of lectins, such as MBL2, FCN1, FCN2 or FCN3, to carbohydrates on the pathogen surface. MASP2 is cleaved and activated by MASP1 in response to lectin-binding to pathogen carbohydrates. Can activate prothrombin to thrombin.
References:
1. Rossi, V. et al. (2001) The Journal of biological chemistry 276, 40880-7. PMID: 11527969
2. Héja, D. et al. (2012) Proceedings of the National Academy of Sciences of the United States of America 109, 10498-503. PMID: 22691502
3. Degn, SE. et al. (2012) Journal of immunology (Baltimore, Md. : 1950) 189, 3957-69. PMID: 22966085
4. Matsushita, M. et al. (2000) Journal of immunology (Baltimore, Md. : 1950) 165, 2637-42. PMID: 10946292
5. Kidmose, RT. et al. (2012) Proceedings of the National Academy of Sciences of the United States of America 109, 15425-30. PMID: 22949645
6. Thiel, S. et al. (1997) Nature 386, 506-10. PMID: 9087411
7. Valenzuela Leon, PC. et al. (2025) Journal of medicinal chemistry 68, 4663-4671. PMID: 39924859
Note: For research use only. Not suitable for clinical or therapeutic use.
Images
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SDS-PAGESDS-PAGE for Research Grade Anti-Human MASP2 (CM338)
